4.6 Article

Integrin α3β1 Represses Reelin Expression in Breast Cancer Cells to Promote Invasion

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Dermatology

Integrin α3β1 on Tumor Keratinocytes Is Essential to Maintain Tumor Growth and Promotes a Tumor-Supportive Keratinocyte Secretome

Whitney M. Longmate et al.

Summary: The study indicates that the α3β1 integrin plays a crucial role in maintaining tumor growth, with its deletion resulting in rapid regression of established skin tumors and affecting the function of tumor cells and associated stroma. α3β1 integrin regulates a significant portion of the keratinocyte secretome and the skin tumor microenvironment, making it a potential therapeutic target.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Dermatology

Integrin α3β1 Is a Key Regulator of Several Protumorigenic Pathways during Skin Carcinogenesis

Veronika Ramovs et al.

Summary: This study reveals the crucial role of integrin alpha 3 beta 1 and CD151 in regulating signaling pathways that control the survival of differentiating keratinocytes, shedding light on the essential role of alpha 3 beta 1 in the early stages of skin cancer development.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Review Biochemistry & Molecular Biology

Hold on or Cut? Integrin- and MMP-Mediated Cell-Matrix Interactions in the Tumor Microenvironment

Stephan Niland et al.

Summary: The tumor microenvironment (TME) is a key focus in cancer research and treatment, involving various components including ECM and modifying enzymes. Cells within the TME interact with the ECM, influencing tumor progression through feedback mechanisms involving cellular receptors, cytokines, and exosomes. Matrix remodeling in the TME, particularly by matrix metalloproteinases (MMPs), plays a crucial role in modifying ECM barriers and releasing soluble ECM fragments that impact cells both within and outside the TME.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Breast cancer statistics, 2019

Carol E. DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Article Medicine, Research & Experimental

Cytoskeletal and extracellular matrix proteins as markers for metastatic triple negative breast cancer

Mohammed Elimam Ahamed Mohammed et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2019)

Review Anatomy & Morphology

Nonneuronal roles for the reelin signaling pathway

Elvira Khialeeva et al.

DEVELOPMENTAL DYNAMICS (2017)

Review Biochemistry & Molecular Biology

The opposing roles of laminin-binding integrins in cancer

Veronika Ramovs et al.

MATRIX BIOLOGY (2017)

Review Oncology

Role of tumor microenvironment in triple-negative breast cancer and its prognostic significance

Tianjian Yu et al.

CHINESE JOURNAL OF CANCER RESEARCH (2017)

Article Oncology

Astrocyte-induced Reelin expression drives proliferation of Her2+ breast cancer metastases

Rahul Jandial et al.

CLINICAL & EXPERIMENTAL METASTASIS (2017)

Review Cell Biology

The role of integrins in TGFβ activation in the tumour stroma

Zareen Khan et al.

CELL AND TISSUE RESEARCH (2016)

Review Neurosciences

Reelin and Neuropsychiatric Disorders

Kazuhiro Ishii et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2016)

Article Biochemistry & Molecular Biology

Cleavage within Reelin Repeat 3 Regulates the Duration and Range of the Signaling Activity of Reelin Protein

Mari Koie et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Signaling events mediated by α3β1 integrin are essential for mammary tumorigenesis

S. Cagnet et al.

ONCOGENE (2014)

Article Multidisciplinary Sciences

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

Josh Neman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Dermatology

Integrin Regulation of Epidermal Functions in Wounds

Whitney M. Longmate et al.

ADVANCES IN WOUND CARE (2014)

Review Cell Biology

The extracellular matrix: A dynamic niche in cancer progression

Pengfei Lu et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Developmental Biology

Disruption of reelin signaling alters mammary gland morphogenesis

Elvira Khialeeva et al.

DEVELOPMENT (2011)

Review Pharmacology & Pharmacy

Integrin α3β1 as a breast cancer target

Sita Subbaram et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2011)

Review Biochemistry & Molecular Biology

Integrin-TGF-β crosstalk in fibrosis, cancer and wound healing

Coert Margadant et al.

EMBO REPORTS (2010)

Review Biochemistry & Molecular Biology

Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets

Christopher S. Stipp

EXPERT REVIEWS IN MOLECULAR MEDICINE (2010)

Article Oncology

Epigenetic silencing of RELN in gastric cancer

Osamu Dohi et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2010)

Review Oncology

Integrins in cancer: biological implications and therapeutic opportunities

Jay S. Desgrosellier et al.

NATURE REVIEWS CANCER (2010)

Article Biochemistry & Molecular Biology

A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay

Stephanie Boelz et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Biochemistry & Molecular Biology

Integrins: Bidirectional, allosteric signaling machines

RO Hynes

Article Biochemistry & Molecular Biology

On the epigenetic regulation of the human reelin promoter

Y Chen et al.

NUCLEIC ACIDS RESEARCH (2002)

Article Biochemistry & Molecular Biology

Reelin is a serine protease of the extracellular matrix

CC Quattrocchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Oncology

Integrin laminin receptors and breast carcinoma progression

AM Mercurio et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2001)

Article Neurosciences

Reelin binds α3β1 integrin and inhibits neuronal migration

L Dulabon et al.

NEURON (2000)