4.6 Review

CDK4/6 Inhibitor Treatments in Patients with Hormone Receptor Positive, Her2 Negative Advanced Breast Cancer: Potential Molecular Mechanisms, Clinical Implications and Future Perspectives

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Drug-Drug Interactions and Pharmacogenomic Evaluation in Colorectal Cancer Patients: The New Drug-PIN(R) System Comprehensive Approach

Michela Roberto et al.

Summary: Drug-drug interactions can impact treatment efficacy and toxicity. Using Drug-PIN (R) software in colorectal cancer patients, researchers found that a doubled DrugPin2 score was significantly associated with severe toxicity, highlighting the software's potential to prevent adverse events and reduce hospitalizations.

PHARMACEUTICALS (2021)

Article Oncology

Clinical Implications of Body Mass Index in Metastatic Breast Cancer Patients Treated With Abemaciclib and Endocrine Therapy

Maria Alice Franzoi et al.

Summary: Adding abemaciclib to endocrine therapy prolongs progression-free survival (PFS) in advanced breast cancer patients regardless of their body mass index (BMI), indicating benefits for both overweight/obese and normal/underweight patients. However, patients with normal and/or underweight BMI may have a better response to abemaciclib treatment compared to overweight and/or obese patients, as shown by higher overall response rates and neutropenia frequency.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Review Oncology

Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition

Monica Alvarez-Fernandez et al.

CANCER CELL (2020)

Review Biochemistry & Molecular Biology

CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions

Rossana Roncato et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER plus breast cancer

Luigi Formisano et al.

NATURE COMMUNICATIONS (2019)

Article Medicine, General & Internal

Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer

Fabrice Andre et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer

S. -A. Im et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cell Biology

MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21

Anna E. Vilgelm et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Oncology

Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors

Stefano Fogli et al.

CANCER TREATMENT REVIEWS (2019)

Review Oncology

Circulating tumor DNA analysis in breast cancer: Is it ready for prime-time?

Giuseppe Buono et al.

CANCER TREATMENT REVIEWS (2019)

Review Oncology

Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review

Kamal Pandey et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Medicine, General & Internal

Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer

N. C. Turner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer

Matthew P. Goetz et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Article Multidisciplinary Sciences

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

Smruthi Vijayaraghavan et al.

NATURE COMMUNICATIONS (2017)

Article Oncology

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance

Ping Chen et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Review Oncology

Treating cancer with selective CDK4/6 inhibitors

Ben O'Leary et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Article Multidisciplinary Sciences

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Xiaoyong Fu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Medicine, General & Internal

Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer

Nicholas C. Turner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Genetics & Heredity

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

Weiyi Toy et al.

NATURE GENETICS (2013)

Article Medicine, Research & Experimental

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

Todd W. Miller et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Oncology

Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer

Alex Xiu-Cheng Fan et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2009)

Review Oncology

Biological determinants of endocrine resistance in breast cancer

Elizabeth A. Musgrove et al.

NATURE REVIEWS CANCER (2009)