4.7 Article

Epiretinal Membrane Surgery: Structural Retinal Changes Correlate with the Improvement of Visual Function

期刊

JOURNAL OF CLINICAL MEDICINE
卷 10, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/jcm10010090

关键词

optical coherence tomography; pars plana vitrectomy; visual acuity; single retinal layer; automated segmentation

资金

  1. Ministry of Health
  2. Fondazione Roma

向作者/读者索取更多资源

This study analyzed structural retinal changes with SD-OCT and found that postoperative thickness decreases of the IRL, INL, and OPL were correlated with visual acuity improvements in patients with ERM undergoing PPV. The re-compaction of these retinal layers after relieving ERM-induced traction may play an important role in postoperative visual function improvement.
Several parameters have been studied for identifying the visual outcomes after pars plana vitrectomy (PPV) for epiretinal membrane (ERM) peeling. This retrospective study aimed to analyze structural retinal changes with spectral domain-optical coherence tomography (SD-OCT) and their correlations with visual acuity improvement in patients with ERM undergoing PPV. Twenty-one pseudophakic eyes were enrolled in the study. Ophthalmic evaluations included best corrected visual acuity (BCVA) and retinal layer thickness measurements with SD-OCT. The segmentation of the retina was divided into four parts: the inner retinal layer (IRL), composed of an internal limiting membrane, retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer; inner nuclear layer (INL); outer plexiform layer (OPL); and outer nuclear layer (ONL). Correlations between changes in retinal layer thicknesses and BCVA were explored over a 6 month follow-up period. The postoperative thickness decrease of the INL was significantly correlated with thickness changes in all other measured retinal layers (p < 0.001). Non-parametric linear regression showed that postoperative improvement in BCVA was associated with a postoperatively decreased thickness in the IRL (p = 0.021), INL (p = 0.039), and OPL (p = 0.021). In eyes undergoing PPV, postoperative thickness decreases of the IRL, INL, and OPL were correlated with visual acuity improvements. Re-compaction of these retinal layers after relieving ERM-induced traction may be an important factor in postoperative visual function improvement.

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