Links between Inflammation and Postoperative Cancer Recurrence

Despite complete resection, cancer recurrence frequently occurs in clinical practice. This indicates that cancer cells had already metastasized from their organ of origin at the time of resection or had circulated throughout the body via the lymphatic and vascular systems. To obtain this potential for metastasis, cancer cells must undergo essential and intrinsic processes that are supported by the tumor microenvironment. Cancer-associated inflammation may be engaged in cancer development, progression, and metastasis. Despite numerous reports detailing the interplays between cancer and its microenvironment via the inflammatory network, the status of cancer-associated inflammation remains difficult to recognize in clinical settings. In the current paper, we reviewed clinical reports on the relevance between inflammation and cancer recurrence after surgical resection, focusing on inflammatory indicators and cancer recurrence predictors according to cancer type and clinical indicators.

Automated summary

Despite complete resection, cancer recurrence is common, indicating possible metastasis of cancer cells. Tumor microenvironment plays a crucial role in cancer development and metastasis, with cancer-associated inflammation possibly contributing to these processes. Although the relationship between inflammation and cancer recurrence has been extensively studied, it remains challenging to identify the status of cancer-associated inflammation in clinical settings.