4.7 Review

Ventricular Assist Device-Specific Infections

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Article Immunology

Epidemiology of Left Ventricular Assist Device Infections: Findings From a Large Nonregistry Cohort

Merilda O. Blanco-Guzman et al.

Summary: VAD infections are a significant complication post-implantation, with the driveline being the most common site of infection and gram-positive bacteria being the primary pathogens. Clinical criteria alone are not sufficient to predict serious infections, and many patients with confirmed infections have normal CT scans. Patients with VAD-specific infections have lower median survival compared to those with VAD-related infections.

CLINICAL INFECTIOUS DISEASES (2021)

Review Radiology, Nuclear Medicine & Medical Imaging

The value of18F-FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device: a systematic review and meta-analysis

D. ten Hove et al.

Summary: FDG-PET/CT is a valuable tool for assessing device-related infections in LVAD patients, with high sensitivity and variable specificity. Standardization of procedures and criteria for suspected infections are needed for consistent reporting.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

Article Engineering, Biomedical

Outcomes Following Left Ventricular Assist Device Exchange: Focus on the Impacts of Device Infection

Gardner Yost et al.

Summary: Hemodynamic support with continuous-flow left ventricular assist device (CF-LVAD) therapy has been shown to be a reliable treatment for advanced heart failure. This study investigated outcomes of LVAD exchange, showing that while less than 11% of patients required device exchange, it can be safely and effectively performed with long-term outcomes similar to primary implantation. The indication for exchange impacts postexchange outcomes, with patients exchanged for LVAD infection faring worse than those exchanged for other reasons.

ASAIO JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)

Enrico Ammirati et al.

Summary: There are geographic variations in the management and outcomes of CF-LVAD patients between the US and Europe, but overall survival rates are similar. Disparities in donor characteristics, duration of support, and adverse events between the US and Europe may explain differences in the utilization of mechanical bridging strategies.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Biofilm formation and migration on ventricular assist device drivelines

Yue Qu et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

Review Cardiac & Cardiovascular Systems

Diagnostic Accuracy of FDG PET/CT in Suspected LVAD Infections A Case Series, Systematic Review, and Meta-Analysis

Marty C. Tam et al.

JACC-CARDIOVASCULAR IMAGING (2020)

Article Cardiac & Cardiovascular Systems

New Treatment for Driveline Infection Following Implantation of a Ventricular Assist Device

Akira Sezai et al.

HEART SURGERY FORUM (2020)

Article Surgery

Two-Year Outcomes in HeartMate 3 versus HeartWare HVAD Patients Implanted as Destination Therapy

L. Coyle et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

Article Cardiac & Cardiovascular Systems

Comparing short-term outcome after implantation of the HeartWare® HVAD® and the Abbott® HeartMate 3®

Rene Schramm et al.

ESC HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

Blood stream infection and outcomes in recipients of a left ventricular assist device

Philipp Angleitner et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2020)

Article Cardiac & Cardiovascular Systems

Characterization of infected, explanted ventricular assist device drivelines: The role of biofilms and microgaps in the driveline tunnel

Yue Qu et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

Article Cardiac & Cardiovascular Systems

The Society of Thoracic Surgeons Intermacs Database Annual Report: Evolving Indications, Outcomes, and Scientific Partnerships

Robert L. Kormos et al.

ANNALS OF THORACIC SURGERY (2019)

Article Cardiac & Cardiovascular Systems

Stroke and death risk in ventricular assist device patients varies by ISHLT infection category: An INTERMACS analysis

Palak Shah et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

Article Medicine, General & Internal

A Fully Magnetically Levitated Left Ventricular Assist Device - Final Report

M. R. Mehra et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Meeting Abstract Cardiac & Cardiovascular Systems

Showering with the Driveline Exit Site Exposed to Well Water Does Not Increase Rates of Driveline Exit Site Infection

C. Ballew et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

Article Engineering, Biomedical

Driveline angle is crucial for preventing driveline infection in patients with HeartMate II device

Yorihiko Matsumoto et al.

JOURNAL OF ARTIFICIAL ORGANS (2019)

Article Engineering, Biomedical

Left ventricular assist device-related infections: does the time of onset matter?

Amy L. Lehnert et al.

JOURNAL OF ARTIFICIAL ORGANS (2019)

Article Cardiac & Cardiovascular Systems

Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry

Margaret M. Hannan et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

Editorial Material Cardiac & Cardiovascular Systems

What Lies Within? Imaging to Detect Ventricular Assist Device Infection

Michael S. Kiernan et al.

JACC-CARDIOVASCULAR IMAGING (2019)

Article Cardiac & Cardiovascular Systems

The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) of the European Association for Cardio-Thoracic Surgery (EACTS): second report

Theo M. M. H. de By et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2018)

Article Cardiac & Cardiovascular Systems

2017 EACTS Guidelines on perioperative medication in adult cardiac surgery

Miguel Sousa-Uva et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2018)

Article Engineering, Biomedical

Therapy and Outcome of Staphylococcus aureus Infections of Intracorporeal Ventricular Assist Devices

Miquel B. Ekkelenkamp et al.

ARTIFICIAL ORGANS (2018)

Review Transplantation

VAD infection during bridge-to-transplant, unique aspects of treatment and prevention

Christine Koval

CURRENT OPINION IN ORGAN TRANSPLANTATION (2018)

Article Engineering, Biomedical

Driveline Site Is Not a Predictor of Infection After Ventricular Assist Device Implantation

Billie-Jean Martin et al.

ASAIO JOURNAL (2018)

Article Cardiac & Cardiovascular Systems

Substantial Reduction in Driveline Infection Rates With the Modification of Driveline Dressing Protocol

Matthew M. Lander et al.

JOURNAL OF CARDIAC FAILURE (2018)

Article Cardiac & Cardiovascular Systems

Cold atmospheric plasma: a new tool for the treatment of superficial driveline infections

Lutz Hilker et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2017)

Article Engineering, Biomedical

Correlation between driveline features and driveline infection in left ventricular assist device selection

Teruhiko Imamura et al.

JOURNAL OF ARTIFICIAL ORGANS (2017)

Article Engineering, Biomedical

Stopping conventional showering decreases Pseudomonas infections in left ventricular assist device patients

Nana Aburjania et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2017)

Article Cardiac & Cardiovascular Systems

An ISHLT consensus document for prevention and management strategies for mechanical circulatory support infection

Shimon Kusne et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2017)

Article Cardiac & Cardiovascular Systems

Prevalence of Cerebral Microbleeds in Patients With Continuous-Flow Left Ventricular Assist Devices

Daisuke Yoshioka et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

Article Cardiac & Cardiovascular Systems

New Treatment for Percutaneous Sites in Patients with a Ventricular Assist Device: Nihon University Crystal Violet Method

Akira Sezai et al.

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY (2016)

Article Infectious Diseases

Ventricular assist devices as bridge to heart transplantation: impact on post-transplant infections

Delphine Hequet et al.

BMC INFECTIOUS DISEASES (2016)

Article Cardiac & Cardiovascular Systems

Surgical management of driveline infections in patients with left ventricular assist devices

Marina Pieri et al.

JOURNAL OF CARDIAC SURGERY (2016)

Article Cardiac & Cardiovascular Systems

Continuous-flow left ventricular assist devices and usefulness of a standardized strategy to reduce drive-line infections

Barbara Cagliostro et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2016)

Article Cardiac & Cardiovascular Systems

Infectious complications after cardiac transplantation in patients bridged with mechanical circulatory support devices versus medical therapy

Brandon C. Varr et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2016)

Review Cardiac & Cardiovascular Systems

Prevention and management of sternal wound infections

Harold L. Lazar et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2016)

Article Cardiac & Cardiovascular Systems

Adverse events in contemporary continuous-flow left ventricular assist devices: A multi-institutional comparison shows significant differences

John M. Stulak et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2016)

Article Surgery

Treatment of Infected Cardiac Implantable Electronic Devices

Abdulla Fakhro et al.

Seminars in Plastic Surgery (2016)

Editorial Material Cardiac & Cardiovascular Systems

Rectus-Sparing Technique for Driveline Insertion of Ventricular Assist Device

S. Yukiko Asaki et al.

ANNALS OF THORACIC SURGERY (2015)

Article Cardiac & Cardiovascular Systems

Outcomes of Heart Transplant After Left Ventricular Assist Device Specific and Related Infection

Michael Z. Tong et al.

ANNALS OF THORACIC SURGERY (2015)

Article Cardiac & Cardiovascular Systems

Management of Rapidly Ascending Driveline Tunnel Infection

Gregory Rubinfeld et al.

JOURNAL OF CARDIAC SURGERY (2015)

Article Cardiac & Cardiovascular Systems

A Simple Education Tool for Ventricular Assist Device Patients and Their Caregivers

Julie Barber et al.

JOURNAL OF CARDIOVASCULAR NURSING (2015)

Article Cardiac & Cardiovascular Systems

Reduction in driveline infection rates: Results from the HeartMate II Multicenter Driveline Silicone Skin Interface (SSI) Registry

David Dean et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2015)

Article Cardiac & Cardiovascular Systems

Seventh INTERMACS annual report: 15,000 patients and counting

James K. Kirklin et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2015)

Review Cardiac & Cardiovascular Systems

Clinical management for complications related to implantable LVAD use

Koichi Toda et al.

GENERAL THORACIC AND CARDIOVASCULAR SURGERY (2015)

Article Cardiac & Cardiovascular Systems

Short and long term outcomes of 200 patients supported by continuous-flow left ventricular assist devices

Athanasios Tsiouris et al.

WORLD JOURNAL OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Early and mid-term outcomes of left ventricular assist device implantation and future prospects

Hiroki Hata et al.

GENERAL THORACIC AND CARDIOVASCULAR SURGERY (2015)

Review Cardiac & Cardiovascular Systems

Fungal Infections Associated with Long-Term Mechanical Circulatory Support-Diagnosis and Management

Jiri Maly et al.

JOURNAL OF CARDIAC SURGERY (2014)

Article Cardiac & Cardiovascular Systems

Evolution and impact of drive-line infection in a Large cohort of continuous-flow ventricular assist device recipients

Christine E. Koval et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2014)

Article Cardiac & Cardiovascular Systems

Drive-line infections and sepsis in patients receiving the HVAD system as a left ventricular assist device

Ranjit John et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2014)

Article Cardiac & Cardiovascular Systems

Management Practices and Major Infections After Cardiac Surgery

Annetine C. Gelijns et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Editorial Material Cardiac & Cardiovascular Systems

Driveline insulation as a conduit for left ventricular assist device pocket infection

Mamatha Pinninti et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2014)

Article Surgery

Salvage of Infected Left Ventricular Assist Device with Antibiotic Beads

James D. Kretlow et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2014)

Article Cardiac & Cardiovascular Systems

A simple device to secure ventricular assist device driveline and prevent exit-site infection

Andrea Baronetto et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2014)

Article Pharmacology & Pharmacy

Clinical practice guidelines for antimicrobial prophylaxis in surgery

D. W. Bratzler et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2013)

Article Cardiac & Cardiovascular Systems

Pump Replacement for Left Ventricular Assist Device Failure Can Be Done Safely and Is Associated With Low Mortality

Nader Moazami et al.

ANNALS OF THORACIC SURGERY (2013)

Article Cardiac & Cardiovascular Systems

Prospective, Multicenter Study of Ventricular Assist Device Infections

Rachel J. Gordon et al.

CIRCULATION (2013)

Article Immunology

Clinical Manifestations and Management of Left Ventricular Assist Device-Associated Infections

Juhsien Jodi C. Nienaber et al.

CLINICAL INFECTIOUS DISEASES (2013)

Review Infectious Diseases

Current concepts in the diagnosis and management of left ventricular assist device infections

Juhsien Nienaber et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2013)

Article Cardiac & Cardiovascular Systems

Fifth INTERMACS annual report: Risk factor analysis from more than 6,000 mechanical circulatory support patients

James K. Kirklin et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2013)

Editorial Material Cardiac & Cardiovascular Systems

CT Angiography and 18F-FDG-PET Fusion Imaging for Prosthetic Heart Valve Endocarditis

Wilco Tanis et al.

JACC-CARDIOVASCULAR IMAGING (2013)

Article Cardiac & Cardiovascular Systems

Radiolabeled WBC Scintigraphy in the Diagnostic Workup of Patients With Suspected Device-Related Infections

Paola A. Erba et al.

JACC-CARDIOVASCULAR IMAGING (2013)

Article Cardiac & Cardiovascular Systems

Risk Analysis of Bloodstream Infection During Long-Term Left Ventricular Assist Device Support

Koichi Toda et al.

ANNALS OF THORACIC SURGERY (2012)

Article Cardiac & Cardiovascular Systems

Driveline Infections in Left Ventricular Assist Devices: Implications for Destination Therapy

Vikas Sharma et al.

ANNALS OF THORACIC SURGERY (2012)

Article Engineering, Biomedical

Double tunnel technique for the LVAD driveline: improved management regarding driveline infections

David Schibilsky et al.

JOURNAL OF ARTIFICIAL ORGANS (2012)

Article Cardiac & Cardiovascular Systems

The Spectrum of Complications Following Left Ventricular Assist Device Placement

Nance Yuan et al.

JOURNAL OF CARDIAC SURGERY (2012)

Article Cardiac & Cardiovascular Systems

Continuous-flow devices and percutaneous site infections: Clinical outcomes

Daniel J. Goldstein et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2012)

Article Cardiac & Cardiovascular Systems

What is the optimum antibiotic prophylaxis in patients undergoing implantation of a left ventricular assist device?

Metesh Nalin Acharya et al.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2012)

Article Cardiac & Cardiovascular Systems

Left Ventricular Assist Device Driveline Infections

Daniel Pereda et al.

CARDIOLOGY CLINICS (2011)

Article Cardiac & Cardiovascular Systems

Surgical Infection Prophylaxis for Left Ventricular Assist Device Implantation

Paul C. Walker et al.

JOURNAL OF CARDIAC SURGERY (2011)

Article Cardiac & Cardiovascular Systems

Temporal Changes in Hospital Costs for Left Ventricular Assist Device Implantation

Mark S. Slaughter et al.

JOURNAL OF CARDIAC SURGERY (2011)

Editorial Material Cardiac & Cardiovascular Systems

Working formulation for the standardization of definitions of infections in patients using ventricular assist devices

Margaret M. Hannan et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2011)

Article Cardiac & Cardiovascular Systems

Infectious complications after pulsatile-flow and continuous-flow left ventricular assist device implantation

Justin M. Schaffer et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2011)

Article Cardiac & Cardiovascular Systems

Role of biofilm in Staphylococcus aureus and Staphylococcus epidermidis ventricular assist device driveline infections

Faustino A. Toba et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2011)

Article Cardiac & Cardiovascular Systems

Infectious Complications in Patients With Left Ventricular Assist Device: Etiology and Outcomes in the Continuous-Flow Era

Veli K. Topkara et al.

ANNALS OF THORACIC SURGERY (2010)

Article Immunology

Risk Factors and Outcomes of Fungal Ventricular-Assist Device Infections

Saima Aslam et al.

CLINICAL INFECTIOUS DISEASES (2010)

Article Microbiology

Candida albicans and Staphylococcus aureus Form Polymicrobial Biofilms: Effects on Antimicrobial Resistance

Melphine M. Harriott et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

Article Cardiac & Cardiovascular Systems

Fungemia Associated with Left Ventricular Assist Device Support

Natasha G. Bagdasarian et al.

JOURNAL OF CARDIAC SURGERY (2009)

Article Cardiac & Cardiovascular Systems

Effect of Left Ventricular Assist Device Infection on Post-transplant Outcomes

Allison R. Schulman et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2009)

Article Cardiac & Cardiovascular Systems

Late-onset driveline infections: The Achilles' heel of prolonged left ventricular assist device support

Andreas Zierer et al.

ANNALS OF THORACIC SURGERY (2007)

Article Immunology

Candidemia in patients with ventricular assist devices

Shmuel Shoham et al.

CLINICAL INFECTIOUS DISEASES (2007)

Article Cardiac & Cardiovascular Systems

The society of thoracic surgeons practice guideline series: Antibiotic prophylaxis in cardiac surgery, part I: Duration

FH Edwards et al.

ANNALS OF THORACIC SURGERY (2006)

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SL Percival et al.

JOURNAL OF HOSPITAL INFECTION (2005)

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Pathogenesis of catheter-related infections: lessons for new designs

A Pascual

CLINICAL MICROBIOLOGY AND INFECTION (2002)

Article Cardiac & Cardiovascular Systems

Nosocomial bloodstream infections in patients with implantable left ventricular assist devices

SM Gordon et al.

ANNALS OF THORACIC SURGERY (2001)

Article Cardiac & Cardiovascular Systems

Fungal left ventricular assist device endocarditis

F Nurozler et al.

ANNALS OF THORACIC SURGERY (2001)