期刊
JOURNAL OF CLINICAL MEDICINE
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/jcm9124039
关键词
Clara cell; lung injury; COPD; bronchopulmonary dysplasia; sarcoidosis; idiopathic pulmonary fibrosis; respiratory infection; asthma
资金
- National Institutes of Health (NIH) [NIH/NHLBI R00 HL141685, NIH/NIAID R03 AI152003]
Club cell secretory protein (CC16) is encoded by the SCGB1A1 gene. It is also known as CC10, secretoglobin, or uteroglobin. CC16 is a 16 kDa homodimeric protein secreted primarily by the non-ciliated bronchial epithelial cells, which can be detected in the airways, circulation, sputum, nasal fluid, and urine. The biological activities of CC16 and its pathways have not been completely understood, but many studies suggest that CC16 has anti-inflammatory and anti-oxidative effects. The human CC16 gene is located on chromosome 11, p12-q13, where several regulatory genes of allergy and inflammation exist. Studies reveal that factors such as gender, age, obesity, renal function, diurnal variation, and exercise regulate CC16 levels in circulation. Current findings indicate CC16 not only may reflect the pathogenesis of pulmonary diseases, but also could serve as a potential biomarker in several lung diseases and a promising treatment for chronic obstructive pulmonary disease (COPD). In this review, we summarize our current understanding of CC16 in pulmonary diseases.
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