期刊
JOURNAL OF CLINICAL MEDICINE
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/jcm9123801
关键词
glutathione peroxidase 3; lung cancer; surgery; recurrence; biomarker
资金
- Chonnam National University Hospital Biomedical Research Institute [BCRI 19041]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education, Science and Technology [2013R1A1A2007187]
- Chonnam National University Hwasun Hospital Institute for Biomedical Science [HCRI 14017-1]
- National Research Foundation of Korea [2013R1A1A2007187] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We aimed to examine the usefulness of serum glutathione peroxidase 3 (GPx3) as a biomarker of lung cancer recurrence after complete resection. We prospectively collected serial serum samples at the baseline, as well as 3, 6 and 12 months after surgery from complete resection cases in 2013. GPx3 levels were measured by enzyme-linked immunosorbent assay. Statistical tests including t-tests and Cox proportional hazard regression analyses were performed. Totally, 135 patients were enrolled, and 39 (28.9%) showed relapse during the median follow-up period (63.60 months; range, 0.167-81.867). The mean GPx3 change was significantly higher in the recurrence group at 6 months (0.32 +/- 0.38 vs. 0.15 +/- 0.29, p = 0.016) and 12 months (0.40 +/- 0.37 vs. 0.13 +/- 0.28, p = 0.001). The high GPx3 change group showed significantly higher 60-months recurrence rates than the low group (48.1% vs. 25.2% at 3 months, p = 0.005; 54.5% vs. 28.9% at 6 months, p = 0.018; 38.3% vs. 18.3% at 12 months, p = 0.035). High GPx3 change at 3 months were independent risk factors of recurrence (hazard ratio (HR) 3.318, 95% confidence interval (CI), 1.582-6.960, p = 0.002) and survival (HR 3.150, 95% CI, 1.301-7.628, p = 0.011). Therefore, serum GPx3 changes after surgery may be useful predictive biomarkers for recurrence in lung cancer. Larger-scale validation studies are warranted to confirm these findings.
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