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Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant α-Synuclein
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Heather Mortiboys et al.
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Olga Martins de Brito et al.
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A disease state mutation unfolds the parkin ubiquitin-like domain
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EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
Cheng Wang et al.
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Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Parkin mediates neuroprotection through activation of IκB kinase/nuclear factor-κB signaling
Iris H. Henn et al.
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A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine
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Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity
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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
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Influence of heterozygosity for Parkin mutation on onset age in familial Parkinson disease : The GenePD study
Mei Sun et al.
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Motor reorganization in asymptomatic carriers of a single mutant Parkin allele:: a human model for presymptomatic parkinsonism
C Buhmann et al.
BRAIN (2005)
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin
SR Sriram et al.
HUMAN MOLECULAR GENETICS (2005)
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila
GH Cha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
AJ Whitworth et al.
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Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations
C Wang et al.
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Parkin-deficient mice are not a robust model of parkinsonism
FA Perez et al.
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Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation
NL Khan et al.
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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Loss of locus coeruleus neurons and reduced startle in parkin null mice
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KKK Chung et al.
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MR Cookson et al.
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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
MS Goldberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
JM Itier et al.
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JC Greene et al.
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Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
T Foroud et al.
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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
F Darios et al.
HUMAN MOLECULAR GENETICS (2003)
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H Shimura et al.
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Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
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