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Reducing Interstitial Fluid Pressure and Inhibiting Pulmonary Metastasis of Breast Cancer by Gelatin Modified Cationic Lipid Nanoparticles
Xuan Gao et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Building Stable MMP2-Responsive Multifunctional Polymeric Micelles by an All-in-One Polymer-Lipid Conjugate for Tumor-Targeted Intracellular Drug Delivery
Qing Yao et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Matrix Metalloproteinase-Responsive Multifunctional Peptide-Linked Amphiphilic Block Copolymers for Intelligent Systemic Anticancer Drug Delivery
Wendong Ke et al.
BIOCONJUGATE CHEMISTRY (2017)
Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy
Tianjiao Ji et al.
ACS NANO (2017)
Beyond a Carrier: Graphene Quantum Dots as a Probe for Programmatically Monitoring Anti-Cancer Drug Delivery, Release, and Response
Hui Ding et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Ligand-Mediated and Enzyme-Directed Precise Targeting and Retention for the Enhanced Treatment of Glioblastoma
Shaobo Ruan et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging
Francois Fay et al.
BIOCONJUGATE CHEMISTRY (2017)
Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release
Huicong Zhou et al.
ACTA BIOMATERIALIA (2017)
Design and Proof of Programmed 5-Aminolevulinic Acid Prodrug Nanocarriers for Targeted Photodynamic Cancer Therapy
Jina Wu et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Smart Asymmetric Vesicles with Triggered Availability of Inner Cell-Penetrating Shells for Specific Intracellular Drug Delivery
Junjie Li et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Prospects for combining targeted and conventional cancer therapy with immunotherapy
Philip Gotwals et al.
NATURE REVIEWS CANCER (2017)
Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization
Qihang Sun et al.
ADVANCED MATERIALS (2017)
Magnetically-responsive, multifunctional drug delivery nanoparticles for elastic matrix regenerative repair
Balakrishnan Sivaraman et al.
ACTA BIOMATERIALIA (2017)
Taming the Wildness of Trojan-Horse Peptides by Charge-Guided Masking and Protease-Triggered Demasking for the Controlled Delivery of Antitumor Agents
Nian-Qiu Shi et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy
Xiaoding Xu et al.
ACS NANO (2017)
Dual Enzymatic Reaction-Assisted Gemcitabine Delivery Systems for Programmed Pancreatic Cancer Therapy
Haijie Han et al.
ACS NANO (2017)
Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism
Xiao Feng et al.
CANCER LETTERS (2017)
Structure-Activity Relationships of JMV4463, a Vectorized CathepsinD Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA-Based Vector
Lubomir L. Vezenkov et al.
CHEMMEDCHEM (2016)
Preparation and evaluation of a non-viral gene vector for SiRNA: Multifunctional envelope-type nano device
Ying Zhang et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2016)
An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer
Tianjiao Ji et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
Star-Shaped Amphiphilic Hyperbranched Polyglycerol Conjugated with Dendritic Poly(L-lysine) for the Codelivery of Docetaxel and MMP-9 siRNA in Cancer Therapy
Xiaoyan Zhou et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
Site-Directed Conjugation of Antibodies to Apoferritin Nanocarrier for Targeted Drug Delivery to Prostate Cancer Cells
Simona Dostalova et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
MMP2-Sensitive PEG-Lipid Copolymers: A New Type of Tumor-Targeted P-Glycoprotein Inhibitor
Zhi Dai et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation
Shaobo Ruan et al.
ACS NANO (2016)
A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan
Xingli Cun et al.
ACTA BIOMATERIALIA (2016)
Protease-Responsive Prodrug with Aggregation-Induced Emission Probe for Controlled Drug Delivery and Drug Release Tracking in Living Cells
Yong Cheng et al.
ANALYTICAL CHEMISTRY (2016)
Structure and function of legumain in health and disease
Elfriede Dall et al.
BIOCHIMIE (2016)
Design of a Small-Molecule Drug Conjugate for Prostate Cancer Targeted Theranostics
Amit Kumar et al.
BIOCONJUGATE CHEMISTRY (2016)
Modular Design and Facile Synthesis of Enzyme-Responsive Peptide-Linked Block Copolymers for Efficient Delivery of Doxorubicin
Wendong Ke et al.
BIOMACROMOLECULES (2016)
Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer
Wei Fan et al.
BIOMATERIALS (2016)
PSMA-specific theranostic nanoplex for combination of TRAIL gene and 5-FC prodrug therapy of prostate cancer
Zhihang Chen et al.
BIOMATERIALS (2016)
MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth
Daniela Kalafatovic et al.
BIOMATERIALS (2016)
A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer
Oren Levy et al.
BIOMATERIALS (2016)
Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment
Xu Song et al.
BIOMATERIALS (2016)
Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy
Shi Gao et al.
BIOMATERIALS (2016)
Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing
A. E. Machulkin et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2016)
Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system
Pei Jing et al.
CANCER LETTERS (2016)
Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors
Daniel D. Von Hoff et al.
CLINICAL CANCER RESEARCH (2016)
Enzyme-responsive polymer hydrogels for therapeutic delivery
Rona Chandrawati
EXPERIMENTAL BIOLOGY AND MEDICINE (2016)
Formulation and dosage of therapeutic nanosuspension for active targeting of docetaxel (WO 2014210485A1)
Deep Pooja et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2016)
Cleaving for growth: threonine aspartase 1-a protease relevant for development and disease
Roland H. Stauber et al.
FASEB JOURNAL (2016)
Caspases Connect Cell-Death Signaling to Organismal Homeostasis
Lorenzo Galluzzi et al.
IMMUNITY (2016)
Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation
Xu-Guang Mi et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)
Functionalized milk-protein-coated magnetic nanoparticles for MRI-monitored targeted therapy of pancreatic cancer
Jing Huang et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)
Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models
Mindy I. Davis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Multifunctional Micellar Nanocarriers for Tumor-Targeted Delivery of Hydrophobic Drugs
Zhi Dai et al.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2016)
Induced Neural Differentiation of MMP-2 Cleaved (RADA) 4 Drug Delivery Systems
K. Koss et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Urokinase-controlled tumor penetrating peptide
Gary B. Braun et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Matrix metalloproteinase-9 (MMP-9) as an activator of nanosystems for targeted drug delivery in pancreatic cancer
Barbara Gruenwald et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Identification of pancreatic tumors in vivo with ligand-targeted, pH responsive mesoporous silica nanoparticles by multispectral optoacoustic tomography
Marie K. Gurka et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn2+ chelator TPEN inducing oxidative stress in prostate cancer cells
Christopher H. Stuart et al.
NANOMEDICINE (2016)
EGCG/gelatin-doxorubicin gold nanoparticles enhance therapeutic efficacy of doxorubicin for prostate cancer treatment
Li-Chu Tsai et al.
NANOMEDICINE (2016)
An enzyme-responsive conjugate improves the delivery of a PI3K inhibitor to prostate cancer
Ashutosh Barve et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)
Targeted delivery of doxorubicin to tumour tissues by a novel legumain sensitive polygonal nanogel
Sen Lin et al.
NANOSCALE (2016)
Lentivirus-mediated knockdown of TSP50 suppresses the growth of non-small cell lung cancer cells via G0/G1 phase arrest
Wen-Liang Qiao et al.
ONCOLOGY REPORTS (2016)
Enzyme-responsive multistage vector for drug delivery to tumor tissue
Yu Mi et al.
PHARMACOLOGICAL RESEARCH (2016)
Mixed Nanosized Polymeric Micelles as Promoter of Doxorubicin and miRNA-34a Co-Delivery Triggered by Dual Stimuli in Tumor Tissue
Giuseppina Salzano et al.
SMALL (2016)
25-methoxyl-dammarane-3β, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation through downregulation of testes-specific protease 50 (TSP50) expression
Danfeng Wang et al.
TUMOR BIOLOGY (2016)
PSA and beyond: alternative prostate cancer biomarkers
Sharanjot Saini
CELLULAR ONCOLOGY (2016)
Controlled release strategy of paclitaxel by conjugating to matrix metalloproteinases-2 sensitive peptide
Changjiang Huang et al.
ONCOTARGET (2016)
MMP-responsive theranostic nanoplatform based on mesoporous silica nanoparticles for tumor imaging and targeted drug delivery
Jing-Jing Hu et al.
JOURNAL OF MATERIALS CHEMISTRY B (2016)
A stimuli-responsive Janus peptide dendron-drug conjugate as a safe and nanoscale drug delivery vehicle for breast cancer therapy
Ning Li et al.
JOURNAL OF MATERIALS CHEMISTRY B (2016)
Efficient delivery of micro RNA to bone-metastatic prostate tumors by using aptamer-conjugated atelocollagen in vitro and in vivo
Zhao Hao et al.
DRUG DELIVERY (2016)
A RNA-DNA Hybrid Aptamer for Nanoparticle-Based Prostate Tumor Targeted Drug Delivery
John C. Leach et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Prostate-Specific Membrane Antigen Targeted Polymersomes for Delivering Mocetinostat and Docetaxel to Prostate Cancer Cell Spheroids
Fataneh Karandish et al.
ACS OMEGA (2016)
Aptamer-modified PLGA nanoparticle delivery of triplex forming oligonucleotide for targeted prostate cancer therapy
J. Jiao et al.
NEOPLASMA (2016)
Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for Single Photon Emission Computed Tomography Imaging and Radiotherapy of Gliomas
Lingzhou Zhao et al.
ACS APPLIED MATERIALS & INTERFACES (2015)
Protease-Activable Cell-Penetrating Peptide-Protoporphyrin Conjugate for Targeted Photodynamic Therapy in Vivo
Shi-Ying Li et al.
ACS APPLIED MATERIALS & INTERFACES (2015)
Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles
Andrew P. Jallouk et al.
BIOCONJUGATE CHEMISTRY (2015)
Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer
Pengfei Xu et al.
BIOMATERIALS (2015)
Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release
Shaobo Ruan et al.
BIOMATERIALS (2015)
Programmed packaging of mesoporous silica nanocarriers for matrix metalloprotease 2-triggered tumor targeting and release
Zhen Zou et al.
BIOMATERIALS (2015)
MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery
Wei-Hai Chen et al.
CHEMICAL COMMUNICATIONS (2015)
Integrin-mediated active tumor targeting and tumor microenvironment response dendrimer-gelatin nanoparticles for drug delivery and tumor treatment
Guanlian Hu et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)
High-yield clicking and dissociation of doxorubicin nanoclusters exhibiting differential cellular uptakes and imaging
Hye Sung Kim et al.
JOURNAL OF CONTROLLED RELEASE (2015)
Enzyme sensitive, surface engineered nanoparticles for enhanced delivery of camptothecin
Hongliang Yu et al.
JOURNAL OF CONTROLLED RELEASE (2015)
PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo
Kadi-Liis Veiman et al.
JOURNAL OF CONTROLLED RELEASE (2015)
Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate
Ying Tu et al.
JOURNAL OF CONTROLLED RELEASE (2015)
Caspase-3 Promotes Genetic Instability and Carcinogenesis
Xinjian Liu et al.
MOLECULAR CELL (2015)
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
Ingrid E. Wertz et al.
NATURE (2015)
Lysosomal cysteine peptidases - Molecules signaling tumor cell death and survival
Anja Pislar et al.
SEMINARS IN CANCER BIOLOGY (2015)
Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment
Guanlian Hu et al.
ONCOTARGET (2015)
The evolution of cancer surgery and future perspectives
Lynda Wyld et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2015)
Metallothion.ein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing
Bong Hwan Park et al.
FEBS LETTERS (2014)
Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity against Solid Tumors and Reduced Potential for Cardiovascular Toxicity
Jason H. Gill et al.
MOLECULAR PHARMACEUTICS (2014)
Enzyme-responsive nanomaterials for controlled drug delivery
Quanyin Hu et al.
NANOSCALE (2014)
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors
Neil D. Rawlings et al.
NUCLEIC ACIDS RESEARCH (2014)
Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy
Celina Ansari et al.
SMALL (2014)
Cysteine Cathepsin Activity Regulation by Glycosaminoglycans
Marko Novinec et al.
BIOMED RESEARCH INTERNATIONAL (2014)
Effects of legumain as a potential prognostic factor on gastric cancers
Na Li et al.
MEDICAL ONCOLOGY (2013)
Correction: Nuclear Legumain Activity in Colorectal Cancer
Mads H. Haugen et al.
PLoS One (2013)
Association of legumain expression pattern with prostate cancer invasiveness and aggressiveness
Yoshio Ohno et al.
WORLD JOURNAL OF UROLOGY (2013)
Emerging roles of cathepsin E in host defense mechanisms
Kenji Yamamoto et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2012)
Cancer chemotherapy: A critical analysis of its 60 years of history
Dario Galmarini et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2012)
Legumain: A biomarker for diagnosis and prognosis of human ovarian cancer
Lina Wang et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway
Zhen-Bo Song et al.
BIOCHEMICAL JOURNAL (2011)
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
Qian Huang et al.
NATURE MEDICINE (2011)
High Expression of Testes-Specific Protease 50 Is Associated with Poor Prognosis in Colorectal Carcinoma
Lei Zheng et al.
PLOS ONE (2011)
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis
J. Dennemaerker et al.
ONCOGENE (2010)
Emerging functional roles of cathepsin E
Nousheen Zaidi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels
R. Navab et al.
ONCOGENE (2008)
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis
Susanna Lewen et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2008)
Matrix metalloproteinases (MMPs): Chemical-biological functions and (Q)SARs
Rajeshwar P. Verma et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
TSP50 encodes a testis-specific protease and is negatively regulated by p53
Haopeng Xu et al.
CANCER RESEARCH (2007)
Identification and characterization of a novel mammalian caspase with proapoptotic activity
L Eckhart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Tumour invasion and matrix metalloproteinases
M Polette et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2004)
Furin at the cutting edge: From protein traffic to embryogenesis and disease
G Thomas
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Protease degradomics:: A new challenge for proteomics
C López-Otin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Lysosomal cysteine proteases: more than scavengers
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BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2000)
Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
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JOURNAL OF CELL BIOLOGY (2000)
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