4.8 Article

Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis

期刊

SCIENCE ADVANCES
卷 7, 期 2, 页码 -

出版社

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abd7600

关键词

-

资金

  1. Welbio-FNRS (Fonds National de la Recherche Scientifique), Belgium
  2. Dutch Diabetes Fonds (DDFR), Holland
  3. Indiana Biosciences Research Institute (IBRI), Indianapolis, Indiana, USA
  4. Innovative Medicines Initiative 2 Joint Undertaking - European Union's Horizon 2020 Research and Innovation Programme [115797, 945268]
  5. Union's Horizon 2020 research and innovation programme
  6. EFPIA
  7. JDRF [2-SRA-2018-493-A-B, 2-SRA-2019-834-S-B]
  8. Leona M. and Harry B. Helmsley Charitable Trust
  9. NIH [R01 DK093954]
  10. VA Merit Award [I01BX001733]

向作者/读者索取更多资源

Research has shown that autoimmune diseases exhibit similar molecular signatures in target tissues, with many related to interferon signaling, which could be targeted for therapy. This suggests that future studies should focus on both the immune system and target tissues, and their interactions.
Autoimmune diseases are typically studied with a focus on the immune system, and less attention is paid to responses of target tissues exposed to the immune assault. We presently evaluated, based on available RNA sequencing data, whether inflammation induces similar molecular signatures at the target tissues in type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. We identified confluent signatures, many related to interferon signaling, indicating pathways that may be targeted for therapy, and observed a high (>80%) expression of candidate genes for the different diseases at the target tissue level. These observations suggest that future research on autoimmune diseases should focus on both the immune system and the target tissues, and on their dialog. Discovering similar disease-specific signatures may allow the identification of key pathways that could be targeted for therapy, including the repurposing of drugs already in clinical use for other diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据