Claisen type Condensation of Methyl Ketones with Carbimidothioates: A New Gateway for the Synthesis of β-Enaminones

Carbimidothioates are synthesized by the reaction of Grignard reagents or heteroaryl lithium compounds with arylisothiocyanates followed by treatment with methyl iodide. Further, application of these intermediates in the synthesis of beta-enaminones by their condensation with methyl ketones in the presence of sodium hydride in DMF is reported. This method offers a new gateway for the synthesis of beta-enaminones, which are important building blocks in synthetic organic chemistry.

Automated summary

Carbimidothioates are synthesized by reacting Grignard reagents or heteroaryl lithium compounds with arylisothiocyanates followed by treatment with methyl iodide. These intermediates are then used to synthesize beta-enaminones by condensation with methyl ketones in the presence of sodium hydride in DMF, providing a new gateway for the synthesis of important building blocks in synthetic organic chemistry.