4.5 Review

Therapeutic Drug Monitoring and Outcome of Infliximab Therapy in Pediatric Onset Inflammatory Bowel Disease

期刊

FRONTIERS IN PEDIATRICS
卷 8, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fped.2020.623689

关键词

anti-TNF; children; Crohn disease; ulcerative colitis; unclassified colitis

资金

  1. Pediatric Research Foundation (Finland)
  2. Helsinki University Hospital Research Fund

向作者/读者索取更多资源

The prevalence of pediatric-onset inflammatory bowel disease (IBD) has been increasing in recent decades, leading to a rise in patients with moderate to severe disease subtype treated with TNF alpha antagonists. While most pediatric patients initially respond to these drugs, dose escalation may be required during the first year of therapy. Due to limited data on therapeutic drug monitoring during therapy with the TNF alpha-blocker adalimumab in pediatric patients, this review focuses on the literature on therapeutic drug monitoring of infliximab and its potential to guide management.
Inflammatory bowel disease (IBD) with pediatric onset has become more prevalent during past decades. Thus, the number of patients with moderate to severe disease subtype treated with antagonists to tumor necrosis factor alpha (TNF alpha) has concurrently risen. Most pediatric patients initially respond to these drugs but will need dose escalation during the first year of therapy. As pediatric data regarding therapeutic drug monitoring during therapy with TNF alpha-blocker adalimumab are sparse, this review focuses on the literature on therapeutic drug monitoring of infliximab and how it may guide management.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据