期刊
FRONTIERS IN PEDIATRICS
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2020.605219
关键词
transcriptome; cell-free RNA; preeclampsia; prediction; preterm birth; IUGR
类别
资金
- Bill and Melinda Gates Foundation
- March of Dimes Prematurity Research Center at Stanford University
- Charles and Marie Robertson Foundation
- Christopher Hess Research Fund
- Charles B. and Ann L. Johnson Endowed Fund
- Chan Zuckerburg Biohub
- Prematurity Research Fund
In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.
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