期刊
ROYAL SOCIETY OPEN SCIENCE
卷 8, 期 1, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsos.201404
关键词
cognitive impairments; oxidative stress; Morris water maze; lead; bi-enzymes
资金
- National Key Research and Development Program of China [2018YFF0215500]
- National Natural Science Foundation of China [21874077]
- Key R&D projects of Jiangsu Province
- Science and Technology R&D Fund of Nantong City [JC2019139]
- Large Instruments Open Foundation of Nantong University
The study showed that poly(lactic-co-glycolic acid) meso-particles containing superoxide dismutase and catalase were effective in attenuating lead-induced cognitive impairment by inhibiting oxidative stress. The bi-enzymes platform displayed a remarkable protective mechanism in preventing memory impairment and reversing lead-induced cognitive impairments.
Oxidative stress has been implicated in the pathogenesis of cognitive impairment. Lead (Pb) is a common environmental toxicant and plays a vital role in oxidative stress activation. In this study, a superoxide dismutase (SOD) and catalase (CAT) containing poly (lactic-co-glycolic acid) (PLGA) meso-particles (PLGA@SOD-CAT) were prepared to attenuate cognitive impairment via inhibiting oxidative stress in rats. It was prepared using a double emulsion (water/oil/water phase) technique to minimize the hazardous effects of Pb burden on cognitive impairment. The meso-particles antagonized the Pb-induced cognitive impairments. Behaviour, serum biochemical parameters and biomarkers of oxidative stress in rats were evaluated after they were subjected to intravenous injection with lead nitrate and PLGA@SOD-CAT. Moreover, the potential protective mechanism of PLGA@SOD-CAT was determined. Notably, PLGA@SOD-CAT appreciably agented memory impairment caused by lead nitrate and it could significantly inhibit Pb-induced oxidative stress in the blood. Furthermore, a remarkable reversion effect of cognitive impairments, including escape latency, crossing platform times and time per cent during the platform quadrant, after PLGA@SOD-CAT administration were noted. Therefore, these results suggested that the bi-enzymes platform was a superior product in eliminating Pb-induced cognitive impairments through reducing expression of Pb-associated oxidative stress, and it could potentially be applied in detoxifying heavy metals in blood circulation.
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