4.6 Review

FTO - A Common Genetic Basis for Obesity and Cancer

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The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA

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IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway

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m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su et al.

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Uncoupling effects of estrogen receptor on LKB1/AMPK interaction upon adiponectin exposure in breast cancer

Loredana Mauro et al.

FASEB JOURNAL (2018)

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Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m6A-YTHDF2-dependent manner

Ruifan Wu et al.

INTERNATIONAL JOURNAL OF OBESITY (2018)

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Targeting autophagy in obesity: from pathophysiology to management

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YTH Domain: A Family of N-6-methyladenosine (m(6)A) Readers

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FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism

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Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

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Critical Enzymatic Functions of FTO in Obesity and Cancer

Xiaolan Deng et al.

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An Assessment of Progress in Cancer Control

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis

Xiaoyi Huang et al.

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N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing

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NUCLEIC ACIDS RESEARCH (2017)

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C. Brooke Steele et al.

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Dynamic RNA Modifications in Gene Expression Regulation

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FTO Polymorphism, Cardiorespiratory Fitness, and Obesity in Brazilian Youth

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JOURNAL OF CLINICAL INVESTIGATION (2015)

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FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

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FTO influences adipogenesis by regulating mitotic clonal expansion

Myrte Merkestein et al.

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Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview

Marta Elena Hernandez-Caballero et al.

MOLECULAR BIOLOGY REPORTS (2015)

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Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5

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Synthesis of a FTO Inhibitor with Anticonvulsant Activity

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N6-methyladenosine-dependent regulation of messenger RNA stability

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A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu et al.

NATURE CHEMICAL BIOLOGY (2014)

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The bigger picture of FTO-the first GWAS-identified obesity gene

Ruth J. F. Loos et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Article Biochemistry & Molecular Biology

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

Jean-Michel Fustin et al.

Article Endocrinology & Metabolism

FTO expression is regulated by availability of essential amino acids

M. K. Cheung et al.

INTERNATIONAL JOURNAL OF OBESITY (2013)

Article Medicine, Research & Experimental

A link between FTO, ghrelin, and impaired brain food-cue responsivity

Efthimia Karra et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemistry & Molecular Biology

Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk

Patricia Amorim da Cunha et al.

MOLECULAR BIOLOGY REPORTS (2013)

Article Multidisciplinary Sciences

Role for the obesity-related FTO gene in the cellular sensing of amino acids

Pawan Gulati et al.

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Ivana Vucenik et al.

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mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

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Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

Baoen Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

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Association of Obesity-related Genetic Variants With Endometrial Cancer Risk: A Report From the Shanghai Endometrial Cancer Genetics Study

Ryan J. Delahanty et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2011)

Article Genetics & Heredity

The role of the fat mass and obesity associated gene (FTO) in breast cancer risk

Virginia Kaklamani et al.

BMC MEDICAL GENETICS (2011)

Article Plant Sciences

Rhein, an inhibitor of adipocyte differentiation and adipogenesis

Qian Liu et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2011)

Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Endocrinology & Metabolism

Multiple signal pathways in obesity-associated cancer

J. Chen

OBESITY REVIEWS (2011)

Article Multidisciplinary Sciences

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Qian Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Endocrinology & Metabolism

Genetic Variation at the FTO Locus Influences RBL2 Gene Expression

Jeremy B. M. Jowett et al.

DIABETES (2010)

Article Biochemistry & Molecular Biology

The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

Tea Berulava et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2010)

Article Multidisciplinary Sciences

Crystal structure of the FTO protein reveals basis for its substrate specificity

Zhifu Han et al.

NATURE (2010)

Article Nutrition & Dietetics

The FTO gene rs9939609 obesity-risk allele and loss of control over eating

Marian Tanofsky-Kraff et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2009)

Article Nutrition & Dietetics

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity

Emily Sonestedt et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2009)

Review Oncology

The Double-Edged Sword of Autophagy Modulation in Cancer

Eileen White et al.

CLINICAL CANCER RESEARCH (2009)

Article Genetics & Heredity

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations

Stephane Cauchi et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2009)

Article Physiology

Regulation of Fto/Ftm gene expression in mice and humans

George Stratigopoulos et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)

Article Cell Biology

Leptin and mTOR

Clarissa M. Maya-Monteiro et al.

CELL CYCLE (2008)

Article Endocrinology & Metabolism

FTO variants are associated with obesity in the Chinese and Malay populations in Singapore

Jonathan T. Tan et al.

DIABETES (2008)

Article Medicine, General & Internal

An Obesity-Associated FTO Gene Variant and Increased Energy Intake in Children

Joanne E. Cecil et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Endocrinology & Metabolism

The FTO gene is associated with adulthood obesity in the Mexican population

Marisela Villalobos-Comparan et al.

OBESITY (2008)

Letter Biochemistry & Molecular Biology

The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae

Steven Robbens et al.

JOURNAL OF MOLECULAR EVOLUTION (2008)

Article Genetics & Heredity

Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina et al.

NATURE GENETICS (2007)

Review Medicine, Research & Experimental

Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer

Emma C. Stuart et al.

LIFE SCIENCES (2006)

Article Medicine, General & Internal

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults

EE Calle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Multidisciplinary Sciences

Mitotic clonal expansion: A synchronous process required for adipogenesis

QQ Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)