Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant

Mesoporous CaCO3 crystals of sizes in the range 3-15 mu m have attracted significant scientific attention as fully decomposable biocompatible drug delivery vectors. They are also used as sacrificial templates to produce polymer-based microcarriers (capsules, beads) and polymer scaffolds for tissue engineering at biologically friendly conditions. However, fabrication of CaCO3 crystals with the sizes beyond the conventional range without additives is still a challenge. There is a desperate need of sub-micrometre and sub-millimetre biocompatible and easily decomposable vectors for intracellular delivery and design of tailor-made polymer scaffolds, respectively. In this study, additive-free one-step fabrication of vaterite mesoporous crystals with sizes in the range from sub micron (0.72 mu m) up to tens of microns (55 mu m) sizes is proposed. Crystals are grown by mixing of Ca2+ and CO32- salts in aqueous media. Internal structure and morphology of the crystals have been investigated. Encapsulation of lysozyme by means of co-synthesis shows an enhanced entrapment into submicron crystals. Besides, the approach to grow CaCO3 crystals on the surface of microcellulose (sic) is demonstrated opening broad avenues for the development of vaterite coatings technologies. (C) 2020 The Author(s). Published by Elsevier Ltd.

Automated summary

Additive-free fabrication of mesoporous vaterite crystals ranging in size from submicron to tens of microns has been successfully achieved, offering new possibilities for drug delivery and tissue engineering in the field of biomedicine.