期刊
SCIENCE BULLETIN
卷 66, 期 14, 页码 1437-1447出版社
ELSEVIER
DOI: 10.1016/j.scib.2021.01.003
关键词
Gene-gene interaction; Co-expression; Structural network; Functional network; Higher-order interactions
资金
- National Key Research and Development Program of China [2017YFA0105203]
- National Natural Science Foundation of China [81671855]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB32040200]
- Beijing Advanced Discipline Fund
The complexity of the human brain is determined by the orchestrated expression of thousands of genes, while pairwise interactions between genes are sufficient to predict the transcriptional pattern of the brain. This quadratic complexity of transcriptional patterns in the human brain, as revealed by the study, highlights the importance of gene-gene interactions in the functional and structural richness of the brain.
The orchestrated expression of thousands of genes gives rise to the complexity of the human brain. However, the structures governing these myriad gene-gene interactions remain unclear. By analyzing transcription data from more than 2000 sites in six human brains, we found that pairwise interactions between genes, without considering any higher-order interactions, are sufficient to predict the transcriptional pattern of the genome for individual brain regions and the transcriptional profile of the entire brain consisting of more than 200 areas. These findings suggest a quadratic complexity of transcriptional patterns in the human brain, which is much simpler than expected. In addition, using a pairwise interaction model, we revealed that the strength of gene-gene interactions in the human brain gives rise to the nearly maximal number of transcriptional clusters, which may account for the functional and structural richness of the brain. (c) 2021 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
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