期刊
ONCOIMMUNOLOGY
卷 10, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2020.1869389
关键词
Adoptive Cell Therapy; ACT; Neoantigen; T cell; Cancer
Personalized adoptive cell therapies (ACT) targeting neoantigens involve identifying suitable personal targets (neoantigens), selecting T cells or their T cell receptors (TCRs) specific for these neoantigens, and expanding the selected T cell population or generating sufficient number of TCR modified T cells. The challenges and approaches to identifying neoantigens and selecting neoantigen-reactive T cells for use in ACT are discussed in this review.
Based on the success of tumor-infiltrating lymphocytes (TIL)-based therapies, personalized adoptive cell therapies (ACT) targeting neoantigens have the potential to become a disruptive technology and lead to highly effective treatments for cancer patients for whom no other options exist. ACT of TIL, peripheral blood or gene-engineered peripheral blood lymphocytes (PBLs) targeting neoantigens is a highly personalized intervention that requires three discrete steps: i) Identification of suitable personal targets (neoantigens), ii) selection of T cells or their T cell receptors (TCRs) that are specific for the identified neoantigens and iii) expansion of the selected T cell population or generation of sufficient number of TCR modified T cells. In this review, we provide an introduction into challenges and approaches to identify neoantigens and to select the Adoptive Cell Therapy, ACT, Neoantigen, T cell, Cancer respective neoantigen-reactive T cells for use in ACT.
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