The forces driving cancer extracellular vesicle secretion

The discovery that cancer cells discharge vast quantities of extracellular vesicles (EVs), underscored the explosion of the EV field. A large body of evidence now supports their onto-functionality in an array of contexts; stromal crosstalk, immune evasion, metastatic site priming, and drug resistance - justifying therapeutic intervention. The current bottleneck is a lack of clear understanding of why and how EV biogenesis ramps up in cancer cells, and hence where exactly avenues for intervention may reside. We know that EVs also play an array of physiological roles, therefore effective anticancer inhibition requires a target distinct enough from physiology to achieve efficacy. Taking the perspective that EV upregulation may be a consequence of the tumor landscape, we examine classic mutational events and tumor characteristics for EV regulators. All the while, aiming to illuminate topics worth further research in therapeutic development.

Automated summary

The discovery of cancer cells releasing large quantities of extracellular vesicles (EVs) has sparked a rapid growth in the field, leading to research on their functions in cancer and potential therapeutic interventions. However, understanding the mechanisms behind EV biogenesis in cancer cells and identifying targets distinct from normal physiology remain key challenges in this area of study.