期刊
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
卷 70, 期 3, 页码 100-105出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.15585/mmwr.mm7003e3
关键词
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The study indicates that the sensitivity of BinaxNOW antigen test is lower in asymptomatic individuals, but with high specificity. Additionally, some antigen test-negative specimens still contained culturable virus.
What is already known about this topic? The BinaxNOW rapid antigen test received Emergency Use Authorization by the Food and Drug Administration for testing specimens from symptomatic persons; performance among asymptomatic persons is not well characterized. What is added by this report? Sensitivity of the BinaxNOW antigen test, compared with polymerase chain reaction testing, was lower when used to test specimens from asymptomatic (35.8%) than from symptomatic (64.2%) persons, but specificity was high. Sensitivity was higher for culture-positive specimens (92.6% and 78.6% for those from symptomatic and asymptomatic persons, respectively); however, some antigen test-negative specimens had culturable virus. What are the implications for public health practice? The high specificity and rapid BinaxNOW antigen test turnaround time facilitate earlier isolation of infectious persons. Antigen tests can be an important tool in an overall community testing strategy to reduce transmission.
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