期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.608976
关键词
TAK1; TABs; post-translational modifications; NF-kappa B; inflammation
类别
资金
- National Natural Science Foundation of China [31870870, 32070773]
- Fundamental Research Funds for the Central Universities [2042019kf0204]
- State Key Laboratory of Veterinary Etiological Biology Grant [SKLVEB2020KFKT002]
- Wuhan University Experiment Technology Project Funding [WHU-2020-SYJS-05]
- Natural Science Foundation of Hubei Province [2018CFA016]
TAK1, a member of the MAPKKK family, functions by assembling with TAB1, TAB2, and TAB3 and can be activated by various stimuli. Post-translational modifications play important roles in controlling the activity, stability, and assembly of the TAK1-TABs complex.
Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding proteins (TAB1, TAB2, and TAB3) and can be activated by a variety of stimuli such as tumor necrosis factor alpha (TNF alpha), interleukin-1 beta (IL-1 beta), and toll-like receptor ligands, and they play essential roles in the activation of NF-kappa B and MAPKs. Numerous studies have demonstrated that post-translational modifications play important roles in properly controlling the activity, stability, and assembly of TAK1-TABs complex according to the indicated cellular environment. This review focuses on the recent advances in TAK1-TABs-mediated signaling and the regulations of TAK1-TABs complex by post-translational modifications.
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