期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.619705
关键词
neutrophil extracellular traps; anti-neutrophil cytoplasmic antibody associated vasculitis; polyarteritis nodosa; Takayasu’ s arteritis; giant cell arteritis; Behcet’ s disease
类别
资金
- Pfizer US Pharmaceuticals Group grant [53857367]
- NIH [R21AR075134, R01 AR074939, R21 AR077266, 1R21EY029391, R21AR075129]
Neutrophils and neutrophil extracellular traps (NETs) contribute to the pathogenesis of many autoimmune diseases, including vasculitis. Though neutrophils, and NETs, can break self-tolerance by being a source of autoantigens for autoantibodies in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, playing a key role in driving the autoimmune response, the role of neutrophils and NETs in large vessel vasculitis, including giant cell arteritis (GCA), is not well understood. In this review, we summarize the current insight into molecular mechanisms contributing to neutrophil-mediated pathology in small and medium vessel vasculitis, as well as provide potential translational perspectives on how neutrophils, and NETs, may partake in large vessel vasculitis, a rare disease entity of unclear pathogenesis.
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