期刊
CURRENT OPINION IN CHEMICAL ENGINEERING
卷 30, 期 -, 页码 86-95出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coche.2020.08.009
关键词
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资金
- Chan Zuckerberg Initiative Ben Barres Early Career Acceleration Award [2018-191850]
- N.I.H. grant [R01 HL122347]
Drug delivery to the central nervous system (CNS) is generally hindered by the selectivity of the blood-brain barrier (BBB). However, there is strong evidence that the integrity of the BBB is compromised under certain pathological conditions, potentially providing a window to deliver drugs to injured brain regions. Recent studies suggest that caveolae-mediated transcytosis, a transport pathway suppressed in the healthy BBB, becomes elevated as an immediate response to ischemic stroke and at early stages of aging, where it may precede irreversible neurological damage. This article reviews early stage caveolar transcytosis as a novel and promising drug delivery opportunity. We propose that albumin-binding and nanoparticle approaches have the potential to leverage this window of transcellular BBB disruption for trafficking therapeutic agents into the CNS.
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