期刊
APPLIED SCIENCES-BASEL
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/app11030891
关键词
bone regeneration; scaffold; tissue engineering; micro-computed tomography; regenerative medicine; bone tissue– material interaction
类别
资金
- Versus Arthritis [21160]
- Rosetree Trust [A1184]
- European Commission via H2020 MSCA RISE programme (BAMOS) [734156]
- Innovate UK via Newton Fund [102872]
- Engineering and Physical Science Research Council (EPSRC) [EP/T517793/1]
- Innovate UK [102872] Funding Source: UKRI
- Marie Curie Actions (MSCA) [734156] Funding Source: Marie Curie Actions (MSCA)
The study examined the impact of scaffolds with and without bone marrow concentrate on subchondral bone regeneration, finding that the composition and addition of BMC did not significantly affect bone regeneration in osteochondral defects after six months. However, the research provides data that may guide the development of future treatments.
Osteochondral scaffold technology has emerged as a promising therapy for repairing osteochondral defects. Recent research suggests that seeding osteochondral scaffolds with bone marrow concentrate (BMC) may enhance tissue regeneration. To examine this hypothesis, this study examined subchondral bone regeneration in scaffolds with and without BMC. Ovine stifle condyle models were used for the in vivo study. Two scaffold systems (8 mm diameter and 10 mm thick) with and without BMC were implanted into the femoral condyle, and the tissues were retrieved after six months. The retrieved femoral condyles (with scaffold in) were examined using micro-computed tomography scans (micro-CT), and the micro-CT data were further analysed by ImageJ with respect to trabecular thickness, bone volume to total volume ratio (BV/TV) ratio, and degree of anisotropy of bone. Statistical analysis compared bone regeneration between scaffold groups and sub-set regions. These results were mostly insignificant (p < 0.05), with the exception of bone volume to total volume ratio when comparing scaffold composition and sub-set region. Additional trends in the data were observed. These results suggest that the scaffold composition and addition of BMC did not significantly affect bone regeneration in osteochondral defects after six months. However, this research provides data which may guide the development of future treatments.
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