期刊
ADVANCED SCIENCE
卷 8, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/advs.202003505
关键词
bioengineering; delivery systems; exosomes; extracellular vesicles; microvesicles
资金
- European Research Council [785800]
- National Centre of Competence in Research (NCCR) for Molecular Systems Engineering
- Projekt DEAL
- European Research Council (ERC) [785800] Funding Source: European Research Council (ERC)
Extracellular vesicles (EVs) are nano-sized secreted vesicles containing various biomolecules, which have low immunogenicity and can functionally modify recipient cells by transferring bioactive constituents. Therefore, they are considered as an excellent candidate for the next generation drug delivery system.
Extracellular vesicles (EVs) are biocompatible, nano-sized secreted vesicles containing many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their low immunogenicity and ability to functionally modify recipient cells by transferring diverse bioactive constituents make them an excellent candidate for a next-generation drug delivery system. Here, the recent advances in EV biology and emerging strategies of EV bioengineering are summarized, and the prospects for clinical translation of bioengineered EVs and the challenges to be overcome are discussed.
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