4.6 Article

Dnajb8, a target gene of SOX30, is dispensable for male fertility in mice

期刊

PEERJ
卷 8, 期 -, 页码 -

出版社

PEERJ INC
DOI: 10.7717/peerj.10582

关键词

Dnajb8; Male fertility; Spermatogenesis

资金

  1. National Natural Science Foundation of China [81901543, 81972641, 81901545, 81971333]
  2. Fundamental Research Funds for the Central Universities [WK9110000063]
  3. State Key Laboratory of Reproductive Medicine [SKLRM-K201904]
  4. National Key Research and Development Project [2019YFA0802600]

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Background. The DNAJ family of molecular chaperones maintains protein homeostasis in mitotic and postmeiotic cells, especially germ cells. Recently, we found that the transcription factor SOX30 initiates transcription of Dnajb8 during late meiosis and spermiogenesis in mouse testes. Methods. We used the CRISPR/Cas9 system to generate Dnajb8 mutant mice and analyze the phenotype of the Dnajb8 mutants. Results. Although Dnajb8 is an evolutionarily conserved gene, it is not essential for spermatogenesis and male fertility. We provide this phenotypic information, which could prevent duplicative work by other groups.

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