A Review of Graphene-Based Surface Plasmon Resonance and Surface-Enhanced Raman Scattering Biosensors: Current Status and Future Prospects

The surface plasmon resonance (SPR) biosensor has become a powerful analytical tool for investigating biomolecular interactions. There are several methods to excite surface plasmon, such as coupling with prisms, fiber optics, grating, nanoparticles, etc. The challenge in developing this type of biosensor is to increase its sensitivity. In relation to this, graphene is one of the materials that is widely studied because of its unique properties. In several studies, this material has been proven theoretically and experimentally to increase the sensitivity of SPR. This paper discusses the current development of a graphene-based SPR biosensor for various excitation methods. The discussion begins with a discussion regarding the properties of graphene in general and its use in biosensors. Simulation and experimental results of several excitation methods are presented. Furthermore, the discussion regarding the SPR biosensor is expanded by providing a review regarding graphene-based Surface-Enhanced Raman Scattering (SERS) biosensor to provide an overview of the development of materials in the biosensor in the future.

Automated summary

The surface plasmon resonance (SPR) biosensor is a powerful analytical tool for investigating biomolecular interactions, and graphene has been widely studied as a material to increase the sensor's sensitivity through various excitation methods. Current development of graphene-based SPR biosensor includes discussion on graphene properties, its application in biosensors, simulation, and experimental results of different excitation methods. Additionally, a review on graphene-based Surface-Enhanced Raman Scattering (SERS) biosensor expands the discussion on SPR biosensors, providing an overview of future material development in biosensors.