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Safety and efficacy of common vitamin D supplementation in primary hyperparathyroidism and coexistent vitamin D deficiency and insufficiency: a systematic review and meta-analysis

期刊

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 44, 期 8, 页码 1667-1677

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SPRINGER
DOI: 10.1007/s40618-020-01473-5

关键词

Primary hyperparathyroidism; Vitamin D deficiency; 25OHD supplementation; Meta-analysis

资金

  1. Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine (CAMS-I2M)
  2. National Natural Science Foundation of China [81100559]

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This study aimed to evaluate the safety and efficacy of vitamin D supplementation in patients with PHPT. The results showed that vitamin D supplementation in PHPT patients with vitamin D deficiency significantly reduces PTH and ALP levels.
Purpose Primary hyperparathyroidism (PHPT) is characterized by excessive secretion of parathyroid hormone (PTH). Vitamin D deficiency can stimulate parathyroid secretion. However, whether to correct vitamin D deficiency in patients with PHPT is controversial. We aimed to evaluate the safety and efficacy of vitamin D replacement in patients with PHPT. Methods We searched PubMed, Cochrane Library, and Embase. The relevant data were extracted from the included documents. The methodological items for non-randomized studies score entries were used for evaluation of quality. Review Manager 5.3 and Stata 12.0 were used for statistical analysis. Results A total of 11 articles were included with a total of 388 patients. The serum calcium mean difference (MD) was - 0.06 mg/dL [95% confidence interval (95% CI) - 0.16, 0.04]. Subgroup analysis showed that serum calcium levels did not change if the intervention time exceeded 1 month. The 24-h urinary calcium MD was 36.78 mg/day (95% CI - 37.15, 110.71), which indicated that there was no significant effect of vitamin D supplementation on 24-h urinary calcium levels. The MD of PTH was - 16.01 pg/mL (95% CI - 28.79, - 3.24). Subgroup analysis according to the intervention time showed that vitamin D intervention for more than 1 month significantly reduced PTH levels. The ALP MD was - 10.81 U/L (95% CI - 13.98, - 7.63), which indicated Vitamin D supplementation reduced its level. The MD of 25-hydroxyvitamin D was 22.09 mu g/L (95% CI 15.01, 29.17), and no source of heterogeneity was found. Conclusion Vitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria.

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