期刊
JOURNAL OF BIOLOGICAL ENGINEERING
卷 15, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13036-021-00255-8
关键词
Selective laser melting; Bone scaffold; Pore geometry; Computational fluid dynamics; Bone ingrowth
资金
- Applied Basic Research Project of Science and Technology Department of Sichuan Province [2020YJ0265]
- Sichuan University-Luzhou Government Strategic Cooperation Project [2019CDLZ-17]
This study revealed the influence of optimal shape of porous titanium alloy scaffolds on bone regeneration through experiments and computational analysis, with diamond lattice structure showing the best effect on bone tissue growth.
The microstructure of porous scaffolds plays a vital role in bone regeneration, but its optimal shape is still unclear. In this study, four kinds of porous titanium alloy scaffolds with similar porosities (65%) and pore sizes (650 mu m) and different structures were prepared by selective laser melting. Four scaffolds were implanted into the distal femur of rabbits to evaluate bone tissue growth in vivo. Micro-CT and hard tissue section analyses were performed 6 and 12 weeks after the operation to reveal the bone growth of the porous scaffold. The results show that diamond lattice unit (DIA) bone growth is the best of the four topological scaffolds. Through computational fluid dynamics (CFD) analysis, the permeability, velocity and flow trajectory inside the scaffold structure were calculated. The internal fluid velocity difference of the DIA structure is the smallest, and the trajectory of fluid flow inside the scaffold is the longest, which is beneficial for blood vessel growth, nutrient transport and bone formation. In this study, the mechanism of bone growth in different structures was revealed by in vivo experiments combined with CFD, providing a new theoretical basis for the design of bone scaffolds in the future.
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