Evidence for Muscle Cell-Based Mechanisms of Enhanced Performance in Stretch-Shortening Cycle in Skeletal Muscle

Force attained during concentric contraction (active shortening) is transiently enhanced following eccentric contraction (active stretch) in skeletal muscle. This phenomenon is called stretch-shortening cycle (SSC) effect. Since many human movements contain combinations of eccentric and concentric contractions, a better understanding of the mechanisms underlying the SSC effect would be useful for improving physical performance, optimizing human movement efficiency, and providing an understanding of fundamental mechanism of muscle force control. Currently, the most common mechanisms proposed for the SSC effect are (i) stretch-reflex activation and (ii) storage of energy in tendons. However, abundant SSC effects have been observed in single fiber preparations where stretch-reflex activation is eliminated and storage of energy in tendons is minimal at best. Therefore, it seems prudent to hypothesize that factor(s) other than stretch-reflex activation and energy storage in tendons contribute to the SSC effect. In this brief review, we focus on possible candidate mechanisms for the SSC effect, that is, pre-activation, cross-bridge kinetics, and residual force enhancement (RFE) obtained in experimental preparations that exclude/control the influence of stretch-reflex activation and energy storage in tendons. Recent evidence supports the contribution of these factors to the mechanism of SSCs, and suggests that the extent of their contribution varies depending on the contractile conditions. Evidence for and against alternative mechanisms are introduced and discussed, and unresolved problems are mentioned for inspiring future studies in this field of research.

Automated summary

The stretch-shortening cycle (SSC) effect in skeletal muscle is characterized by transient enhancement of force during concentric contraction following eccentric contraction. Proposed mechanisms for this effect include stretch-reflex activation, energy storage in tendons, pre-activation, cross-bridge kinetics, and residual force enhancement. Studies suggest that factors other than stretch-reflex activation and tendon energy storage contribute to the SSC effect, with varying degrees of contribution depending on contractile conditions. Further research is needed to explore alternative mechanisms and unresolved issues in this field.