The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases

This review highlights recent findings about the role that endothelial glycocalyx and caveolae play in vascular homeostasis. We describe the structure, synthesis, and function of glycocalyx and caveolae in vascular cells under physiological and pathophysiological conditions. Special focus will be given in glycocalyx and caveolae that are associated with impaired production of nitric oxide (NO) and generation of reactive oxygen species (ROS). Such alterations could contribute to the development of cardiovascular diseases, such as atherosclerosis, and hypertension.

Automated summary

This review summarizes the role of endothelial glycocalyx and caveolae in vascular homeostasis, with a focus on their association with impaired nitric oxide production and reactive oxygen species generation, which may contribute to the development of cardiovascular diseases.