期刊
FRONTIERS IN PHYSIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2020.593026
关键词
blood– brain barrier; cerebrovascular disease; dynamic contrast enhanced MRI; Parkinson’ s disease; neurovascular unit
类别
资金
- Engineering and Physical Sciences Research Council [EP/M005909/1]
- Lancashire Teaching Hospitals NHS Foundation Trust
- Lancaster University
- University of Manchester
- EPSRC [EP/S031510/1, EP/M005909/1, EP/S031367/1] Funding Source: UKRI
Background Blood-brain barrier (BBB) disruption has been noted in animal models of Parkinson's disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking. Objective To determine alterations in BBB integrity in PD, with comparison to cerebrovascular disease. Methods Dynamic contrast enhanced magnetic resonance images were collected from 49 PD patients, 15 control subjects with cerebrovascular disease [control positive (CP)] and 31 healthy control subjects [control negative (CN)], with all groups matched for age. Quantitative maps of the contrast agent transfer coefficient across the BBB (K-trans) and plasma volume (v(p)) were produced using Patlak analysis. Differences in K-trans and v(p) were assessed with voxel-based analysis as well as in regions associated with PD pathophysiology. In addition, the volume of white matter lesions (WMLs) was obtained from T-2-weighted fluid attenuation inversion recovery (FLAIR) images. Results Higher K-trans, reflecting higher BBB leakage, was found in the PD group than in the CN group using voxel-based analysis; differences were most prominent in the posterior white matter regions. Region of interest analysis confirmed K-trans to be significantly higher in PD than in CN, predominantly driven by differences in the substantia nigra, normal-appearing white matter, WML and the posterior cortex. WML volume was significantly higher in PD compared to CN. K-trans values and WML volume were similar in PD and CP, suggesting a similar burden of cerebrovascular disease despite lower cardiovascular risk factors. Conclusion These results show BBB disruption in PD.
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