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FRONTIERS IN PHARMACOLOGY (2012)
A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase
David M. Taylor et al.
ACS CHEMICAL BIOLOGY (2011)
The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
Cheol Woong Ha et al.
AGING-US (2011)
Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
Brendon J. Gurd
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2011)
Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation
Sun Haeng Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Peptide Switch Is Essential for Sirt1 Deacetylase Activity
Hyeog Kang et al.
MOLECULAR CELL (2011)
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
David J. Bonda et al.
LANCET NEUROLOGY (2011)
Nicotinamide improves motor deficits and upregulates PGC-1 alpha and BDNF gene expression in a mouse model of Huntington's disease
Tyisha Hathorn et al.
NEUROBIOLOGY OF DISEASE (2011)
Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
Gisa Ellrichmann et al.
PLOS ONE (2011)
Neuropathological Alterations in Alzheimer Disease
Alberto Serrano-Pozo et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)
Mammalian Sirtuins: Biological Insights and Disease Relevance
Marcia C. Haigis et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Protective Effect of Sesamol against 3-Nitropropionic Acid-Induced Cognitive Dysfunction and Altered Glutathione Redox Balance in Rats
Puneet Kumar et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2010)
Role of Sirtuin 1 in metabolic regulation
Jose P. Silva et al.
DRUG DISCOVERY TODAY (2010)
SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology
Kai Harting et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2010)
Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease
Daniel J. Ho et al.
EXPERIMENTAL NEUROLOGY (2010)
SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
Han Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
Michelle Pacholec et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)
Kilian Huber et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
An Overview of APP Processing Enzymes and Products
Vivian W. Chow et al.
NEUROMOLECULAR MEDICINE (2010)
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
Ruth Luthi-Carter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
Eric Verdin et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
A Combination Therapy of Donepezil and Cilostazol for Patients With Moderate Alzheimer Disease: Pilot Follow-Up Study
Heii Arai
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2009)
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors
Takayoshi Suzuki et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest
Toshiaki Inoue et al.
CELL CYCLE (2009)
Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
Dirk Beher et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2009)
Impaired PGC-1α function in muscle in Huntington's disease
Rajnish K. Chaturvedi et al.
HUMAN MOLECULAR GENETICS (2009)
Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity
Federico Medda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by α-synuclein or amyloid-β (1-42) peptide
Diego Albani et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
Carl Julien et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)
CBP/p300-mediated acetylation of histone H3 on lysine 56
Chandrima Das et al.
NATURE (2009)
Sirt2 interacts with 14-3-3 β/γ and down-regulates the activity of p53
Yun-Hye Jin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
Sonia Lain et al.
CANCER CELL (2008)
Biological and Potential Therapeutic Roles of Sirtuin Deacetylases
D. M. Taylor et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Resveratrol: A natural compound with pharmacological potential in neurodegenerative diseases
Hector I. Rocha-Gonzalez et al.
CNS NEUROSCIENCE & THERAPEUTICS (2008)
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
Judit Pallos et al.
HUMAN MOLECULAR GENETICS (2008)
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
Ruwin Pandithage et al.
JOURNAL OF CELL BIOLOGY (2008)
Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau
Kim N. Green et al.
JOURNAL OF NEUROSCIENCE (2008)
Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK
Hyo Jin Kim et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2008)
The SIRT2 Deacetylase Regulates Autoacetylation of p300
Joshua C. Black et al.
MOLECULAR CELL (2008)
Metabolic adaptations through the PGC-1α and SIRT1 pathways
Joseph T. Rodgers et al.
FEBS LETTERS (2008)
Syntheses of nicotinamide riboside and derivatives: Effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells
Tianle Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
NATURE (2007)
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Nicholas A. Bishop et al.
NATURE REVIEWS GENETICS (2007)
Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (Sirtuins)
Johannes Trapp et al.
CHEMMEDCHEM (2007)
Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis
Brian J. North et al.
PLOS ONE (2007)
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
Fei Wang et al.
AGING CELL (2007)
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
Tiago Fleming Outeiro et al.
SCIENCE (2007)
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
Dohoon Kim et al.
EMBO JOURNAL (2007)
Sirtuins in mammals: insights into their biological function
Shaday Michan et al.
BIOCHEMICAL JOURNAL (2007)
Resveratrol stimulates AMP kinase activity in neurons
Biplab Dasgupta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacrtylase SIRT1
Masaya Tanno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin
Anja Schuetz et al.
STRUCTURE (2007)
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
Cherie M. Southwood et al.
NEUROCHEMICAL RESEARCH (2007)
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress
T. Inoue et al.
ONCOGENE (2007)
Role of brain-derived neurotrophic factor in Huntington's disease
Chiara Zuccato et al.
PROGRESS IN NEUROBIOLOGY (2007)
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells:: Effect of histone deacetylase inhibitors
Jorge M. A. Oliveira et al.
JOURNAL OF NEUROSCIENCE (2006)
2-anilinobenzamides as SIRT inhibitors
Takayoshi Suzuki et al.
CHEMMEDCHEM (2006)
Effect of resveratral on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms
Puneet Kumar et al.
BEHAVIOURAL PHARMACOLOGY (2006)
One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development
M. Gonzalez-Santiago et al.
ATHEROSCLEROSIS (2006)
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
Weiping Qin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Neuronal protection by sirtuins in Alzheimer's disease
TS Anekonda et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
AD Napper et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
J Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanism of human SIRT1 activation by resveratrol
MT Borra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Substrate-specific activation of sirtuins by resveratrol
M Kaeberlein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
S Nemoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanism of sirtuin inhibition by nicotinamide:: Altering the NAD+ cosubstrate specificity of a Sir2 enzyme
JL Avalos et al.
MOLECULAR CELL (2005)
Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases
S Ghosh et al.
HUMAN MOLECULAR GENETICS (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
F Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
HY Cohen et al.
SCIENCE (2004)
Molecular pathways to neurodegeneration
E Bossy-Wetzel et al.
NATURE MEDICINE (2004)
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
A Vaquero et al.
MOLECULAR CELL (2004)
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases
MD Jackson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene
M Hiratsuka et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
AA Sauve et al.
BIOCHEMISTRY (2003)
Recent advances in drug-induced neuropathies
AC Peltier et al.
CURRENT OPINION IN NEUROLOGY (2002)
NF-kappa B at the crossroads of life and death
M Karin et al.
NATURE IMMUNOLOGY (2002)
Chemistry of gene silencing:: The mechanism of NAD+-dependent deacetylation reactions
AA Sauve et al.
BIOCHEMISTRY (2001)
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
CM Grozinger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure of the histone deacetylase SIRT2
MS Finnin et al.
NATURE STRUCTURAL BIOLOGY (2001)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
S Imai et al.
NATURE (2000)
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