期刊
FRONTIERS IN PHARMACOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2020.611087
关键词
Salvia miltiorrhiza; tanshinone IIA; anticancer; mechanism; traditional Chinese medicine
资金
- National Key Research and Development project [2017YFC1702702]
- Shandong Provincial Technological Innovation and Guidance Project [2017YFC1702702]
Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge. It has been used in China and neighboring countries for treating various diseases, including cancer. Current research on the anticancer effects and mechanisms of Tan IIA is relatively scattered, but it shows promising potential in cancer treatment.
Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan IIA is currently used in China and other neighboring countries to treat patients with cardiovascular system, diabetes, apoplexy, arthritis, sepsis, and other diseases. Recently, it was reported that tan IIA could have a wide range of antitumor effects on several human tumor cell lines, but the research of the mechanism of tan IIA is relatively scattered in cancer. This review aimed to summarize the recent advances in the anticancer effects of tan IIA and to provide a novel perspective on clinical use of tan IIA.
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