期刊
FRONTIERS IN PHARMACOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2020.598175
关键词
siRNA; PEGylated lipid-based nanoparticles; target; delivery systems; mechanism
资金
- National Science Foundation of China [81601596, 31770921, 31971187]
RNA interference technology holds great potential for clinical application by unraveling disease mechanisms; the challenge lies in improving stability, bioactivity, and efficiency of delivering therapeutic agents to target sites. PEGylated lipid-based delivery system, with its advantages of long circulating half-life, low toxicity, and biocompatibility, provides a promising platform for targeted delivery of nucleic acids and is advancing towards clinical trials for siRNA delivery.
RNA interference (RNAi) technology has become a powerful tool in application of unraveling the mechanism of disease and may hold the potential to be developed for clinical uses. Small interfering RNA (siRNA) can bind to target mRNA with high specificity and efficacy and thus inhibit the expression of related protein for the purpose of treatment of diseases. The major challenge for RNAi application is how to improve its stability and bioactivity and therefore deliver therapeutic agents to the target sites with high efficiency and accuracy. PEGylated lipid-based delivery system has been widely used for development of various medicines due to its long circulating half-life time, low toxicity, biocompatibility, and easiness to be scaled up. The PEGylated lipid-based delivery system may also provide platform for targeting delivery of nucleic acids, and some of the research works have moved to the phases for clinical trials. In this review, we introduced the mechanism, major challenges, and strategies to overcome technical barriers of PEGylated lipid-based delivery systems for advanced target delivery of siRNA in vivo. We also summarized recent advance of PEGylated lipid-based siRNA delivery systems and included some successful research works in this field.
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