期刊
EMERGING MICROBES & INFECTIONS
卷 10, 期 1, 页码 376-383出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2020.1863132
关键词
SARS-CoV-2; natural infection; domestic cats; households; viral shedding
资金
- Programa Fondecyt de Iniciacion [11170877]
- Proyecto FIV
- CRIP (Center for Research for Influenza Pathogenesis), a NIAID [HHSN272201400008C]
- JPB Foundation [2020-215611 (5384)]
- Office of Research Infrastructure of the National Institutes of Health (NIH) [S10OD018522, S10OD026880]
- Robin Chemers Neustein Postdoctoral Fellowship Award
- FONDECYT [1161971]
- Agencia Nacional de Investigacion y Desarrollo (ANID) from Chile.Fondo Nacional de Desarrollo Cientifico y Tecnologico [ACT 1408]
- Programa Beca Magister Nacional de ANID [22190312]
This study described a household with two human adults and three cats infected with SARS-CoV-2. One female cat was asymptomatically infected, and the virus showed human-to-cat transmission.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in domestic and wild cats. However, little is known about natural viral infections of domestic cats, although their importance for modelling disease spread, informing strategies for managing positive human-animal relationships and disease prevention. Here, we describe the SARS-CoV-2 infection in a household of two human adults and sibling cats (one male and two females) using real-time RT-PCR, an ELISA test, viral sequencing, and virus isolation. On May 5th, 2020, the cat-owners tested positive for SARS-CoV-2. Two days later, the male cat showed mild respiratory symptoms and tested positive. Four days after the male cat, the two female cats became positive, asymptomatically. Also, one human and one cat showed antibodies against SARS-CoV-2. All cats excreted detectable SARS-CoV-2 RNA for a shorter duration than humans and viral sequences analysis confirmed human-to-cat transmission. We could not determine if cat-to-cat transmission also occurred.
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