期刊
CATALYSTS
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/catal10121419
关键词
enzymatic synthesis; β -amino alcohols; reactor; epoxides; ring-opening reaction
资金
- Natural Science Foundation of Zhejiang Province [LGN20C200020]
- Key Research & Development Projects of Zhejiang Province [2020C03090]
- Zhejiang Provincial Key Discipline of Chemistry Biology
- National Science and Technology Support Project [2015BAD14B0305]
- National Natural Science Foundation of China [21306172]
- Science and Technology Research Program of Zhejiang Province [2014C32094]
- Natural Science Foundation of Zhejiang University of Technology [116004029]
An efficient method for the preparation of beta-amino alcohols catalyzed by lipase TL IM from Thermomyces lanuginosus in a continuous-flow reactor was developed. The eco-friendly biocatalyst combined with continuous-flow reaction technology displayed high efficiency in the synthesis of beta-amino alcohols. The benign reaction conditions (35 degrees C) and short residence time (20 min), together with the use of low cost and readily available starting materials, make this synthetic approach a promising alternative to current beta-amino alcohol synthesis.
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