期刊
CARTILAGE
卷 13, 期 2_SUPPL, 页码 427S-437S出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1947603520973240
关键词
articular cartilage; knee; biomechanics; mechanical testing
类别
资金
- AOA Research Grant [528]
- Victorian Medical Research Acceleration Fund
- Melbourne Medical School Mid Career Seeding Grant
- University of Melbourne
The study characterized the elastic and viscoelastic properties of human knee articular cartilage, providing valuable insights for evaluating tissue-engineered materials and reporting a range of biomechanical properties for human distal femoral articular cartilage for the first time.
Objectives Recapitulating the mechanical properties of articular cartilage (AC) is vital to facilitate the clinical translation of cartilage tissue engineering. Prior to evaluation of tissue-engineered constructs, it is fundamental to investigate the biomechanical properties of native AC under sudden, prolonged, and cyclic loads in a practical manner. However, previous studies have typically reported only the response of native AC to one or other of these loading regimes. We therefore developed a streamlined testing protocol to characterize the elastic and viscoelastic properties of human knee AC, generating values for several important parameters from the same sample. Design Human AC was harvested from macroscopically normal regions of distal femoral condyles of patients (n = 3) undergoing total knee arthroplasty. Indentation and unconfined compression tests were conducted under physiological conditions (temperature 37 degrees C and pH 7.4) and testing parameters (strain rates and loading frequency) to assess elastic and viscoelastic parameters. Results The biomechanical properties obtained were as follows: Poisson ratio (0.4 +/- 0.1), instantaneous modulus (52.14 +/- 9.47 MPa) at a loading rate of 1 mm/s, Young's modulus (1.03 +/- 0.48 MPa), equilibrium modulus (7.48 +/- 4.42 MPa), compressive modulus (10.60 +/- 3.62 MPa), dynamic modulus (7.71 +/- 4.62 MPa) at 1 Hz and loss factor (0.11 +/- 0.02). Conclusions The measurements fell within the range of reported values for human knee AC biomechanics. To the authors' knowledge this study is the first to report such a range of biomechanical properties for human distal femoral AC. This protocol may facilitate the assessment of tissue-engineered composites for their functionality and biomechanical similarity to native AC prior to clinical trials.
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