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Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm

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Review Neurosciences

The placenta-brain-axis

Cheryl S. Rosenfeld

Summary: The placenta is a structurally diverse organ in mammals that not only facilitates exchange of gases and nutrients, but also produces hormones and neurotransmitters influencing maternal physiology and fetal development. Placental responses to in utero stressors may have long-term health outcomes, particularly impacting brain development. This intimate relationship between the placenta and brain has led to the term placenta-brain-axis, which is being studied for its effects on later neurobehavioral disorders.

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