期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-020-00738-8
关键词
Cancer cell membrane; Mesoporous silica nanoparticles; Isoimperatorin; Apoptosis; Lymphom
资金
- National Natural Science Foundation of China [8157120841, 82001165]
- Fundamental Research Funds for the Central Universities of Central South University [2019zzts366]
- guiding project of Qinghai Provincial Health and Family Planning Commission [2018-wjzdx-17, 2020-wjzdx-38]
This study proposes a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), camouflaged by the cancer cell membrane (CCM), called CCM@MSNs-ISOIM. This nano-platform features immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility, and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.
BackgroundNon-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells.ResultsAccordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.ConclusionsFurthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据