期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 9, 期 23, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.120.018649
关键词
Buchinger fasting; hypertension; weight loss
资金
- Amplius GmbH, Uberlingen, Germany
Background: We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0 +/- 3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results: Subjects underwent a multidisciplinary fasting program with a daily intake of approximate to 250 kcal. Weight and stress scores decreased during fasting, and the well-being index increased, documenting a good tolerability. BP mean values decreased from 126.2 +/- 18.6/81.4 +/- 11.0 to 119.7 +/- 15.9/77.6 +/- 9.8 mm Hg (mean change, -6.5/3.8 mm Hg). BP changes were larger for hypertensive nonmedicated subjects (>140/90 mm Hg) and reduced by 16.7/8.8 mm Hg. This reduction reached 24.7/13.1 mm Hg for hypertensive nonmedicated subjects (n=76) with the highest BP (>160/100 mm Hg). In the normotensive group, BP decreased moderately by 3.0/1.9 mm Hg. Interestingly, we documented an increase of 6.3/2.2 mm Hg in a subgroup of 69 female subjects with BP <100/60 mm Hg. In the hypertensive medicated group, although BP decreased from 134.6/86.0 to 127.3/81.3 mm Hg, medication was stopped in 23.6% of the subjects, whereas dosage was reduced in 43.5% and remained unchanged in 19.4%. The decrease in BP was larger in subjects fasting longer. Baseline metabolic parameters, such as body mass index and glucose levels, as well as age, can be used to predict the amplitude of the BP decrease during fasting with a machine learning model. Conclusions: Long-term fasting tends to decrease BP in subjects with elevated BP values. This effect persisted during the 4 days of stepwise food reintroduction, even when subjects stopped their antihypertensive medication. REGISTRATION: URL: https://www.drks.de/drks_web/; Unique identifier: DRKS00010111.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据