期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 71, 期 9, 页码 647-655出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2021.1876055
关键词
Cyclodextrin; hyaluronic acid; poloxamer; supramolecular gel
Mechanically enhanced poloxamer (F127)-based injectable hydrogels in the presence of hyaluronic acid (HA) and three types of cyclodextrin (CD) molecules were prepared in this study. The addition of HA and CD molecules improved the performance of the gels, making them more mucoadhesive.
Mechanically enhanced poloxamer (F127)-based injectable hydrogels in the presence of hyaluronic acid (HA) and three types of cyclodextrin (CD) molecules were prepared. With the addition of HA to the F127 system, higher strain values to break down the interactions between the micelles were obtained. The formulations exhibit more frequency-dependent behavior than F127-HA gels with the inclusion of CD molecules. All the F127-HA-CD formulations containing alpha-, beta- and gamma-CD were found in the injectable range and the viscosity values increased considerably when mucin was added to the triple component formulations that prove the mucoadhesive properties of the gels.
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