期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.604462
关键词
probiotics; microRNA; gut microbiota; homeostasis; host-microbe interactions
类别
资金
- National Natural Science Foundation of China [31970503]
- Sichuan Science and Technology Program [2021GJHZ0140, 2019YFH0060]
- Basic scientific research projects of Sichuan scientific research institutes [SASA201906]
This paper discusses the roles of probiotics and miRNAs in host-microbe interactions, proposes the association of probiotics with altered miRNAs in intestinal diseases and potential mechanisms, and provides a perspective on the probiotics-miRNA-host/gut microbiota axis for disease management highly associated with the gut microbiome in future studies.
Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis - the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host-microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host-microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics-miRNA-host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies.
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