期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.610070
关键词
antibiotic-resistant bacteria; traditional Chinese medicine; active ingredients; reversion mechanism; multi-drug resistance
类别
资金
- National Natural Science Foundation of China [81973468, 81973712, 81803680]
- Department of Science and Technology Outstanding Young Talents Foundation of Jilin [20180520056JH]
- Jilin Province Science and Technology Development Project in China [20170309005YY, 20200708081YY]
- Jilin Province TCM science and technology project [2020041]
Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditional Chinese medicine (TCM). Here, we summarized the inhibitory mechanism of TCM herbs and their active ingredients on bacteria, discussed the regulatory mechanism of TCM on antibiotic-resistant bacteria, and revealed preclinical results of TCM herbs and their active components against antibiotic-resistant bacteria in mouse models. Those data suggest that TCM herbs and their effective constituents exhibit potential blockage ability on antibiotic-resistant bacteria, providing novel therapeutic ideas for reversing antibiotic resistance.
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