Reconsidering the evidence for learning in single cells

The question of whether single cells can learn led to much debate in the early 20th century. The view prevailed that they were capable of non-associative learning but not of associative learning, such as Pavlovian conditioning. Experiments indicating the contrary were considered either non-reproducible or subject to more acceptable interpretations. Recent developments suggest that the time is right to reconsider this consensus. We exhume the experiments of Beatrice Gelber on Pavlovian conditioning in the ciliate Paramecium aurelia, and suggest that criticisms of her findings can now be reinterpreted. Gelber was a remarkable scientist whose absence from the historical record testifies to the prevailing orthodoxy that single cells cannot learn. Her work, and more recent studies, suggest that such learning may be evolutionarily more widespread and fundamental to life than previously thought and we discuss the implications for different aspects of biology.

Automated summary

The question of whether single cells can learn sparked debate in the early 20th century, with recent developments suggesting that their learning abilities may be more widespread and fundamental than previously thought. Beatrice Gelber's experiments on Pavlovian conditioning in Paramecium aurelia may challenge the prevailing belief that single cells cannot learn, shedding light on different aspects of biology.