期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 49, 期 1, 页码 11-19出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2020.1862134
关键词
Carbon dots; Artemisiae Argyi Folium Carbonisata; anti-frostbite; blood glucose levels
资金
- National Natural Science Foundation of China [81573573]
- Classical Prescription Basic Research Team of Beijing University of Chinese Medicine
The novel carbon dots (CDs) were discovered and separated from Artemisiae Argyi Folium Carbonisata (AAFC) aqueous extract in this study. The AAFC-CDs were characterized by various methods and showed potential for clinical applications in treating frostbite by reducing tissue damage and increasing energy supply.
In this study, novel carbon dots (CDs) were discovered and separated from Artemisiae Argyi Folium Carbonisata (AAFC) aqueous extract. AAFC-CDs were characterised by a series of methods, mainly including electron microscopy, optical technology and X-ray photoelectron spectroscopy (XPS). Results displayed that AAFC-CDs with a quantum yield (QY) around 0.19% had a size distribution between 6.0 and 10.0 nm and possessed a nearly spherical shape, with a lattice spacing of 0.369 nm. In mice, AAFC-CDs reduced the tissue damage, ear frostbite, and body stiffness caused by cold, and provided energy by increasing the use of blood glucose. The mechanism may be by decreasing concentration of IL-1 beta k, TNF-alpha and reducing the rise in blood glucose levels caused by frostbite. This study is the first to indicate that CDs may be the active constituent of AAFC against frostbite, suggesting their potential for clinical applications.
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