期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 9, 期 4, 页码 1846-1855出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.0c08262
关键词
allylic amination; nickel catalysis; N-heterocycles; allylic alcohols; organic carbonate; green chemistry
资金
- Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Gov. of India
- DST-SERB Ramanujan Fellowship, Gov. of India [SB/S2/RJN135/2017]
- DST-SERB Start-up Research Grant, Gov. of India [SRG/2020/000658/CS]
This translation discusses a method of synthesis using carbonate-enabled allylic cross-amination reactions under nickel catalysis, showing high selectivity and successful application in the Ni-catalyzed green allylic amination reactions to synthesize a range of organic compounds.
A borrowing carbonate-enabled allylic cross-amination reactions employing allylic alcohol were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield pi-allyINi-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles and allylic alcohols. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields.
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