期刊
TOXINS
卷 12, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/toxins12120765
关键词
phytopathogens; Fusarium; mycotoxin contamination; secondary metabolism; beauvericin; enniatin
资金
- National Science Centre OPUS 8 grant [NCN 2014/15/B/NZ9/01544]
- National Science Centre PRELUDIUM 13 grant [NCN 2017/25/N/NZ9/02525]
Most of the fungi from the Fusarium genus are pathogenic to cereals, vegetables, and fruits and the products of their secondary metabolism mycotoxins may accumulate in foods and feeds. Non-ribosomal cyclodepsipeptides are one of the main mycotoxin groups and include beauvericins (BEAs), enniatins (ENNs), and beauvenniatins (BEAEs). When ingested, even small amounts of these metabolites significantly affect human and animal health. On the other hand, in view of their antimicrobial activities and cytotoxicity, they may be used as components in drug discovery and processing and are considered as suitable candidates for anti-cancer drugs. Therefore, it is crucial to expand the existing knowledge about cyclodepsipeptides and to search for new analogues of these compounds. The present manuscript aimed to highlight the extensive variability of cyclodepsipeptides by describing chemistry, biosynthesis, and occurrence of BEAs, ENNs, and BEAEs in foods and feeds. Moreover, the co-occurrence of Fusarium species was compared to the amounts of toxins in crops, vegetables, and fruits from different regions of the world.
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