期刊
POLYMERS
卷 13, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/polym13030360
关键词
alginate; cellulose; gelatin; biomimetic microsphere; hemostasis; antibacterial
资金
- National Natural Science Foundation of China [81803339]
- Natural Science Foundation of Zhejiang Province [LY18H300008]
- Zhejiang Provincial Top Key Discipline of Biology
- 521 Talent Cultivation Plan of Zhejiang Sci-Tech University
Biomimetic microspheres prepared by spray drying containing alginate/carboxymethylcellulose/gelatin and coated with different berberine proportions showed effectiveness in inducing platelet adhesion/aggregation and promoting hemostasis, with BACG-6B exhibiting superior hemostatic performance and strong antibacterial activity compared to the commercial hemostatic agent CMPHP. These novel biomaterials also demonstrated good hemocompatibility and biocompatibility, suggesting potential for broad applications in the future as a dual-functional (hemostat/antibacterial) biomedical material.
Biomimetic microspheres containing alginate/carboxymethylcellulose/gelatin and coated with 0%, 1%, 3%, and 6% berberine (BACG, BACG-1B, BACG-3B, BACG-6B) were prepared by the oil-in-water emulsion method combined with spray drying. Through a series of physicochemical parameters and determination of hemostatic properties in vitro and in vivo, the results indicated that BACG and BACG-Bs were effective in inducing platelet adhesion/aggregation and promoting the hemostatic potential due to their biomimetic structure and rough surface. In addition, BACG-6B with high berberine proportion presented better hemostatic performance compared with the commercial hemostatic agent compound microporous polysaccharide hemostatic powder (CMPHP). BACG-6B also showed strong antibacterial activity in the in vitro test. The hemolysis test and cytotoxicity evaluation further revealed that the novel composite biomaterials have good hemocompatibility and biocompatibility. Thus, BACG-6B provides a new strategy for developing a due-functional (hemostat/antibacterial) biomedical material, which may have broad and promising applications in the future.
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