期刊
POLYMERS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/polym13020194
关键词
curcumin; hyaluronic acid; HA-pNIPAM; thermoresponsive nanogel
资金
- Ratchadapisek Somphote Fund for Postdoctoral Fellowship, Chulalongkorn University (JAL), TSRI Fund [CU_FRB640001_01_33_3]
- Chulalongkorn Academic Advancement into Its Second Century (CUAASC) Project
- National Research University Project, Office of Higher Education Commission [NRU59-047-AM]
- National Natural Science Foundation of China [21750110445]
The synthesized HA-pNIPAM nanogel showed great potential as a delivery vehicle for hydrophobic bioactive compounds, with enhanced aqueous solubility, cytocompatibility, and anti-proliferative activity. This thermoresponsive nanogel platform could be optimized for controlled-release systems encapsulating pharmaceuticals for therapeutic applications.
A hyaluronic acid-grafted poly(N-isopropylacrylamide) (HA-pNIPAM) was synthesized as a polymeric nanogel platform for encapsulation and delivery of hydrophobic bioactive compounds using curcumin as a model drug. As demonstrated by transmission electron microscopy and dynamic light scattering techniques, the HA-pNIPAM was simply assembled into spherical nano-sized particles with the thermoresponsive behavior. The success of curcumin aqueous solubilization was confirmed by fluorescent spectroscopy. The resulting nanogel formulation enhanced the aqueous solubility and uptake into NIH-3T3 cells of curcumin. This nanogel formulation also demonstrates cytocompatibility against NIH-3T3 cells, which deems it safe as a delivery vehicle. Moreover, the formulation has a slight skin-protection effect using an artificial skin equivalence model. The curcumin-loaded HA-pNIPAM nanogel showed an anti-proliferative activity against MDA-MB-231, Caco-2, HepG2, HT-29, and TNF-alpha-induced hyperproliferation of keratinocyte (HaCaT) cells. The thermoresponsive HA-pNIPAM nanogel reported here could be further optimized as a platform for controlled-release systems to encapsulate pharmaceuticals for therapeutic applications.
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